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Convection patterns gradients of non-living and living micro-entities in hydrogels

Canadas, Raphael Faustino; Patrício, Pedro; Brancato, Virginia; Gasperini, Luca; Caballero, David; Pires, Ricardo A; Costa, João B.; Pereira, Hélder

Inducing thermal gradients in two injected fluid systems results in the temporal formation of mixing conductive streams. If preserved through sol-gel transition, this mechanism can be used to drive and pattern non-living and living entities in mixed hydrogels. Interfaces are vital in nature, where gradients of non-living and living entities build distinct yet continuous integrated living tissues. However, the c...


Convection patterns gradients of non-living and living micro-entities in hydrogels

Canadas, Raphaël F.; Patricio, Pedro; Brancato, Virginia; Gasperini, Luca; Caballero, David; Pires, Ricardo A.; Costa, João; Pereira, Hélder; Yong, Ping

Inducing thermal gradients in two injected fluid systems results in the temporal formation of mixing conductive streams. If preserved through sol-gel transition, this mechanism can be used to drive and pattern non-living and living entities in mixed hydrogels. Interfaces are vital in nature, where gradients of non-living and living entities build distinct yet continuous integrated living tissues. However, the c...


Silk fibroin/amniotic membrane 3D bi-layered artificial skin

Gholipourmalekabadi, Mazaher; Samadikuchaksaraei, Ali; Seifalian, Alexander M.; Urbanska, Aleksandra M.; Ghanbarian, Hossein; Hardy, John G.

Burn injuries have been reported to be an important cause of morbidity and mortality and they are still considered as unmet clinical need. Although there is a myriad of effective stem cells that have been suggested for skin regeneration, there is no one ideal scaffold. The aim of this study was to develop a three-dimensional (3D) bi-layer scaffold made of biological decellularized human amniotic membrane (AM) w...


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