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Non-tuberculous cutaneous mycobacterioses,
Nogueira,Lais Bastos; Garcia,Carina Nogueira; Costa,Marcela Santos Corrêa da; Moraes,Monica Brauner de; Kurizky,Patrícia Shu; Gomes,Ciro MartinsAbstract Non-tuberculous mycobacteriosis, previously known as atypical, anonymous, opportunistic, or unclassified mycobacteriosis, refers to pathogenic mycobacterioses other than those caused by Mycobacterium tuberculosis and Mycobacterium leprae. These mycobacteria are known for their environmental distribution, mainly in water and soil. The incidence of non-tuberculous mycobacteriosis has been increasing in a...
Dramatic secukinumab-mediated improvements in refractory leprosy-related neurit...
Kurizky,Patrícia Shu; Motta,Jorgeth de Oliveira Carneiro da; Bezerra,Natanael Victor Furtunato; Sousa,Marcia Carolline dos Santos; Corazza,DaniloAbstract A 39-year-old woman was diagnosed with relapsed multibacillary leprosy and refractory neuritis. Here, we describe an evident loss of therapeutic effectiveness after the third pulse of corticosteroids, which may be attributed to tachyphylaxis and the posterior modulation of interferon- γ (IFN-γ), tumor necrosis factor- α (TNF-α,) interleukin-17A (IL-17A), and IL-12/23p40 after the induction phase of sec...
The interference of polypharmacy and the importance of clinical pharmacy advice...
Cerqueira,Selma Regina Penha Silva; Santos,Lais Sevilha dos; Morelo,Elaine Faria; Santos Júnior,Agenor de Castro Moreira dosAbstract INTRODUCTION: Although supervised doses are essential for reducing leprosy treatment failure, the impact of specific drug interactions has rarely been assessed. This study aimed to estimate the risk of leprosy treatment suspension in patients receiving polypharmacy. METHODS We performed this case-control study in which the primary outcome was defined as the need to discontinue multibacillary leprosy tr...