5 documents found, page 1 of 1
Global guideline for the diagnosis and management of candidiasis: an initiative...
Cornely, Oliver A.; Sprute, Rosanne; Bassetti, Matteo; Chen, Sharon C-A; Groll, Andreas H.; Kurzai, Oliver; Lass-Flörl, CorneliaCandida species are the predominant cause of fungal infections in patients treated in hospital, contributing substantially to morbidity and mortality. Candidaemia and other forms of invasive candidiasis primarily affect patients who are immunocompromised or critically ill. In contrast, mucocutaneous forms of candidiasis, such as oral thrush and vulvovaginal candidiasis, can occur in otherwise healthy individual...
ECMM CandiReg - A ready to use platform for outbreaks and epidemiological studies
Koehler, Philipp; Arendrup, Maiken Cavling; Arikan‐Akdagli, Sevtap; Bassetti, Matteo; Bretagne, Stéphane; Klingspor, Lena; Lagrou, KatrienBackground: Recent outbreaks of Candida auris further exemplify that invasive Candida infections are a substantial threat to patients and healthcare systems. Even short treatment delays are associated with higher mortality rates. Epidemiological shifts towards more resistant Candida spp. require careful surveillance. Objectives: Triggered by the emergence of C auris and by increasing antifungal resistance rates...
IL-10 overexpression predisposes to invasive aspergillosis by suppressing antif...
Cunha, Cristina; Gonçalves, Samuel M.; Duarte-Oliveira, Claudio; Leite, Luis; Lagrou, Katrien; Marques, António; Lupianez, Carmen B.; Mesquita, Inês[Excerpt] To the Editor: Proinflammatory immune responses are critically required for antimicrobial host defenses; however, excessive inflammation has the potential to damage host tissues thereby paradoxically contributing to the progression of infection.[...]
IL-10 overexpression predisposes to invasive aspergillosis by suppressing antif...
Cunha, Cristina; Gonçalves, Samuel M.; Duarte-Oliveira, Cláudio; Leite, Luís; Lagrou, Katrien; Marques, António; Lupiañez, Carmen B.; Mesquita, InêsProinflammatory immune responses are critically required for antimicrobial host defenses; however, excessive inflammation has the potential to damage host tissues thereby paradoxically contributing to the progression of infection. A central negative regulator of inflammatory responses is IL-10, an immunosuppressive cytokine with a wide variety of functions across multiple cell types. Although the role of IL-10 ...
Neutrophil responses to Aspergillosis : new roles for old players
Cunha, Cristina; Kurzai, Oliver; Löffler, Jürgen; Aversa, Franco; Romani, Luigina; Carvalho, AgostinhoNeutrophils are professional phagocytic cells that play a crucial role in innate immunity. Through an assortment of antifungal effector mechanisms, neutrophils are essential in controlling the early stages of fungal infection. These mechanisms range from the production of reactive oxygen intermediates and release of antimicrobial enzymes to the formation of complex extracellular traps that aid in the eliminatio...