9 documents found, page 1 of 1
Enzyme-responsive vitamin D-based micelles for paclitaxel-controlled delivery a...
Peixoto, Diana; Ravasco, João M. J. M.; Blanco Fernandez, Barbara; Veiga, Francisco; Concheiro, Angel; Conde, João; Paiva-Santos, Ana CláudiaPublisher Copyright: © 2025 The Authors; Pancreatic ductal adenocarcinoma (PDAC) remains one of the most feared diseases worldwide owing to its poor prognosis, negligible therapeutic advances, and high mortality. Herein, multifunctional enzyme-responsive micelles for the controlled delivery of paclitaxel (PTX) were prepared to circumvent its current clinical challenges. Accordingly, two enzyme-responsive struct...
New Advances in Biomedical Application of Polymeric Micelles
Figueiras, Ana; Domingues, Cátia; Jarak, Ivana; Santos, Ana Isabel; Parra, Ana; Pais, Alberto; Alvarez-Lorenzo, Carmen; Concheiro, AngelAbstract In the last decade, nanomedicine has arisen as an emergent area of medicine, which studies nanometric systems, namely polymeric micelles (PMs), that increase the solubility and the stability of the encapsulated drugs. Furthermore, their application in dermal drug delivery is also relevant. PMs present unique characteristics because of their unique core-shell architecture. They are colloidal dispersions...
Resveratrol-loaded hydrogel contact lenses with antioxidant and antibiofilm per...
Vivero-Lopez, María; Muras, Andrea; Silva, Diana; Serro, Ana Paula; Otero, Ana; Concheiro, Angel; Alvarez-Lorenzo, CarmenContact lenses (CLs) are prone to biofilm formation, which may cause severe ocular infections. Since the use of antibiotics is associated with resistance concerns, here, two alternative strategies were evaluated to endow CLs with antibiofilm features: copolymerization with the antifouling monomer 2-methacryloyloxyethyl phosphorylcholine (MPC) and loading of the antioxidant resveratrol with known antibacterial a...
A new era for sterilization based on supercritical CO2 technology
Ribeiro, Nilza; Soares, Gonçalo C.; Santos-Rosales, Víctor; Concheiro, Angel; Alvarez-Lorenzo, Carmen; García-González, Carlos A.; Oliveira, Ana L.The increasing complexity in morphology and composition of modern biomedical materials (e.g., soft and hard biological tissues, synthetic and natural‐based scaffolds, technical textiles) and the high sensitivity to the processing environment requires the development of innovative but benign technologies for processing and treatment. This scenario is particularly applicable where current conventional techniques ...
Osteogenic poly(ε-caprolactone)/poloxamine homogeneous blends prepared by super...
Matos, Maria B. C. de; Puga, Ana M.; Alvarez-Lorenzo, Carmen; Concheiro, Angel; Braga, Mara E. M.; Sousa, Hermínio C. deHomogeneous poly(ε-caprolactone) (PCL) and poloxamines (PLXs) porous blends were prepared using a supercritical carbon dioxide-assisted foaming/mixing (SFM) approach aiming to obtain cytocompatible implantable materials presenting tunable morphologies, bioerosion rates, bioactive molecules release and osteogenic features. Pure PCL, pure PLXs (T908 and T1107 varieties) and three distinct PCL:PLX 75:25, 50:50, 25...
Fast and mild strategy, using superhydrophobic surfaces, to produce collagen/pl...
Lima, A. C.; Mano, J. F.; Concheiro, Angel; Alvarez-Lorenzo, CarmenPlatelet lysate (PL) was encapsulated in collagen (Coll) millimetric gel beads, on biomimetic superhydrophobic surfaces, under mild conditions, with the aim of obtaining easy-to-handle formulations able to provide sustained release of multiple growth factors for skin ulcers treatment. The gel particles were prepared with various concentrations of PL incorporating or not stem cells, and tested as freshly prepare...
Bioinspired superamphiphobic surfaces as a tool for polymer-and solvent-indepen...
Rial-Hermida, Maria Isabel; Oliveira, Nuno M.; Concheiro, Angel; Alvarez-Lorenzo, Carmen; Mano, J. F.Superamphiphobic surfaces were evaluated as a tool to prepare spherical particles from polymers and solvents of very diverse nature, under mild conditions and with 100% drug encapsulation yield. Different from bioinspired superhydrophobic surfaces suitable only for aqueous dispersions, the superamphiphobic platforms allowed the formation of spherical droplets when solvents of any polarity were deposited onto th...
Free and copolymerized gamma-cyclodextrins regulate performance of dexamethason...
Lima, A. C.; Puga, Ana M.; Mano, J. F.; Concheiro, Angel; Alvarez-Lorenzo, CarmenPolymeric particles acting as source of biological cues to promote tissue regeneration are currently an interesting topic in bone tissue engineering research. In this study, microspheres of dextran-methacrylated (dextran-MA) and γ-cyclodextrins (γ-CD) for the delivery of osteogenic agents were prepared by means of photopolymerization on biomimetic superhydrophobic surfaces. The effects of the incorporation of t...
Pectin-coated chitosan microgels crosslinked on superhydrophobic surfaces for 5...
Puga, Ana M.; Lima, A. C.; Mano, J. F.; Concheiro, Angel; Alvarez-Lorenzo, Carmen5-Fluorouracil(5-FU)-loaded chitosan microgels for oral and topical chemotherapy were prepared applying a superhydrophobic surface-based encapsulation technology. Drug-loaded chitosan dispersions were cross-linked and then coated with drug-free chitosan or pectin layers at the solid-air interface in a highly<br>efficient and environment-friendly way. The size of the microgels (with diameters of ca.280 and 557um ...