7 documents found, page 1 of 1
Mutational profle of Brazilian lung adenocarcinoma unveils association of EGFR ...
Leal, Letícia Ferro; Paula, Flávia Escremim de; De Marchi, Pedro; Viana, Luciano de Souza; Pinto, Gustavo Dix Junqueira; Carlos, Carolina DiasLung cancer is the deadliest cancer worldwide. The mutational frequency of EGFR and KRAS genes in lung adenocarcinoma varies worldwide per ethnicity and smoking. The impact of EGFR and KRAS mutations in Brazilian lung cancer remains poorly explored. Thus, we investigated the frequency of EGFR and KRAS mutations in a large Brazilian series of lung adenocarcinoma together with patients' genetic ancestry, clinicop...
Relationship between fusobacterium nucleatum, inflammatory mediators and microR...
Proença, Marcela Alcântara [UNESP]; Biselli, Joice Matos [UNESP]; Succi, Maysa [UNESP]; Severino, Fábio Eduardo [UNESP]; Berardinelli, Gustavo NorizMade available in DSpace on 2019-10-06T16:11:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-12-21; Made available in DSpace on 2019-10-06T16:11:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-12-21; AIM To examine the effect of Fusobacterium nucleatum (F. nucleatum ) on the microenvironment of colonic neoplasms and the expression of inflammatory mediators and microRNAs (miRNAs). METHODS Lev...
Microbiota profile and impact of fusobacterium nucleatum in colorectal cancer p...
de Carvalho, Ana Carolina; de Mattos Pereira, Leandro; Datorre, José Guilherme; Dos Santos, Wellington; Berardinelli, Gustavo NorizMicrobial diversity has been pointed out as a major factor in the development and progression of colorectal cancer (CRC). We sought to explore the richness and abundance of the microbial community of a series of colorectal tumor samples treated at Barretos Cancer Hospital, Brazil, through 16S rRNA sequencing. The presence and the impact of Fusobacterium nucleatum (Fn) DNA in CRC prognosis was further evaluated ...
Advantage of HSP110 (T17) marker inclusion for microsatellite instability (MSI)...
Berardinelli, Gustavo Noriz; Scapulatempo-Neto, Cristovam; Durães, Ronílson; Oliveira, Marco Antônio de; Guimarães, Denise; Reis, R. M.Colorectal cancer (CRC) is a leading cause of cancer death worldwide. Microsatellite instability (MSI) is a genetic pathway leading to CRC, associated with particular clinicopathological features, and recently a major biomarker of immunotherapy response. There is little information the frequency MSI among Brazilian CRC patients, and it is still debatable the ideal methodology for MSI screening in countries with...
Relationship between Fusobacterium nucleatum, inflammatory mediators and microR...
Proença, Marcela Alcântara; Biselli, Joice Matos; Succi, Maysa; Severino, Fábio Eduardo; Berardinelli, Gustavo Noriz; Caetano, Alaor; Reis, R. M.AIM To examine the effect of Fusobacterium nucleatum (F. nucleatum) on the microenvironment of colonic neoplasms and the expression of inflammatory mediators and microRNAs (miRNAs). METHODS Levels of F. nucleatum DNA, cytokine gene mRNA (TLR2, TLR4, NFKB1, TNF, IL1B, IL6 and IL8), and potentially interacting miRNAs (miR-21-3p, miR-22-3p, miR-28-5p, miR-34a-5p, miR-135b-5p) were measured by quantitative polymera...
Molecular characterization of short-term primary cultures and comparison with c...
Cruvinel-Carloni, Adriana; Silva-Oliveira, Renato; Torrieri, Raul; Bidinotto, Lucas Tadeu; Berardinelli, Gustavo Noriz; Oliveira-Silva, Viviane AlineBackground: Glioblastoma, the most frequent and malignant adult brain tumor, has been extensively studied. However, there is no effective treatment, and to overcome this challenging scenario, it is essential to improve preclinical biological models. This study aimed to molecularly characterize short-term glioblastoma primary cultures and to compare them with patient tumor profiles. Methods: Glioblastoma cell li...
Molecular profiling of a rare rosette-forming glioneuronal tumor arising in the...
Bidinotto, Lucas Tadeu; Scapulatempo-Neto, Cristovam; Mackay, Alan; de Almeida, Gisele Caravina; Scheithauer, Bernd Walter; Berardinelli, Gustavo NorizRosette-forming glioneuronal tumor (RGNT) of the IV ventricle is a rare and recently recognized brain tumor entity. It is histologically composed by two distinct features: a glial component, resembling pilocytic astrocytoma, and a component forming neurocytic rosettes and/or perivascular rosettes. Herein, we describe a 33-year-old man with RGNT arising in the spinal cord. Following an immunohistochemistry valid...