19 documents found, page 1 of 2
Core-shell catalysts for conventional oxidation of alcohols: a brief review
Correia, Luís M. M.; Kuznetsov, Maxim L.; Alegria, ElisabeteThis review highlights recent research on the application of core–shell structured materials as catalysts in the oxidation of alcohols to value-added products, such as benzaldehyde, acetophenone, benzophenone, cinnamaldehyde, and vanillin, among others. While the application of various unconventional energy inputs (such as microwave and ultrasound irradiation) was reported, this paper focuses on conventional he...
Ugi Adducts of Isatin as Promising Antiproliferative Agents with Druglike Prope...
Brandão, Pedro; Puerta, Adrián; Padrón, José M.; Kuznetsov, Maxim L.; Burke, Anthony J.; Pineiro, MartaMolecular hybridization is a valuable approach in drug discovery. Combining it with multicomponent reactions is highly desirable, since structurally diverse libraries can be attained efficiently in an eco-friendly manner. In this work, isatin is used as key building block for the Ugi 4-center 3-component reaction synthesis of oxindole-lactam hybrids, under catalyst-free conditions. The resulting oxindole-β-lact...
Cu(II) complexes derived from N-carboxymethyl and N-carboxyethyl amino acids as...
Adão, Pedro; Teixeira, Carlos M.; Carvalho, M. Fernanda N.N.; Kuznetsov, Maxim L.; Gomes, Clara S.B.; Pessoa, João CostaThe synthesis, characterization and catalytic performance of chiral Cu(II) complexes derived from N-carboxymethylated and N-carboxyethylated amino acids is reported. The ligand precursors are prepared by single step N-alkylation of the sodium salts of the appropriate chiral amino acid with either sodium chloroacetate or sodium 3-chloropropionate in water. The Cu(II) complexes are obtained upon reaction of Cu(CH...
Efficient solvent-free friedel-crafts benzoylation and acylation of m-xylene ca...
Roy Barman, Tannistha; Sutradhar, Manas; Alegria, Elisabete; Guedes Da Silva, M. Fátima C.; Kuznetsov, Maxim L.; Pombeiro, ArmandoReaction of N-acetylpyrazine-2-carbohydrazide (H2L) with anhydrous Fe(II) or Fe(III) chloride in CH3CN or in MeOH leads to the mononuclear [Fe(kNN’O-HL)Cl2] (1) or binuclear [Fe(kNN’O-HL) Cl(μ-OMe)]2 (2) Fe(III) complex, respectively. These complexes are characterized by elemental analysis, ESI-MS, IR spectroscopy, single-crystal X-ray crystallography, electrochemical techniques and DFT calculations. The theore...
Efficient solvent-free friedel-crafts benzoylation and acylation of m-Xylene ca...
Roy Barman, Tannistha; Sutradhar, Manas; Alegria, Elisabete; Guedes Da Silva, M. Fátima C.; Kuznetsov, Maxim L.; Pombeiro, ArmandoReaction of N-acetylpyrazine-2-carbohydrazide (H2L) with anhydrous Fe(II) or Fe(III) chloride in CH3CN or in MeOH leads to the mononuclear [Fe(kappa NN'O-HL)Cl-2] (1) or binuclear [Fe(kNN'O-HL) Cl(mu-OMe)](2) (2) Fe(III) complex, respectively. These complexes are characterized by elemental analysis, ESI-MS, IR spectroscopy, single-crystal X-ray crystallography, electrochemical techniques and DFT calculations. T...
Tuning cyclohexane oxidation: combination of microwave irradiation and ionic li...
Da Costa Ribeiro, Ana Paula; Martins, Luisa; Kuznetsov, Maxim L.; Pombeiro, ArmandoFor the first time, microwave (MW) irradiation was successfully applied to peroxidative cyclohexane oxidation catalyzed by a C-scorpionate complex, [FeCl2(Tpm)] (1; Tpm = hydrotris(pyrazol-1-yl)methane), providing a highly selective and fast eco-friendly procedure to produce a KA (cyclohexanol + cyclohexanone) oil mixture (up to ca. 100% selectivity) with 28% yield in 1 h at 50 degrees C in MeCN. Water, organic...
Interaction of [(VO)-O-IV(acac)(2)] with Human Serum Transferrin and Albumin
Correia, Isabel; Chorna, Ielyzaveta; Cavaco, Isabel; Roy, Somnath; Kuznetsov, Maxim L.; Ribeiro, Nadia; Justino, Goncalo; Marques, FernandaVO(acac)(2)] is a remarkable vanadium compound and has potential as a therapeutic drug. It is important to clarify how it is transported in blood, but the reports addressing its binding to serum proteins have been contradictory. We use several spectroscopic and mass spectrometric techniques (ESI and MALDI-TOF), small-angle X-ray scattering and size exclusion chromatography (SEC) to characterize solutions contai...
Organocatalyzed oxidation of benzyl alcohols by a tetrazole-amino-saccharin: A ...
Frija, Luis M. T.; Kuznetsov, Maxim L.; Rocha, Bruno G. M.; Cabral, Lília; Cristiano, Maria Lurdes Santos; Kopylovich, Maximilian N.A new catalytic system for the anaerobic oxidation of benzyl alcohols using a tetrazole-amino-saccharin organocatalyst has been established. In a solvent-free and microwave assisted process comprising aqueous tert-butyl hydroperoxide (TBHP) as oxidant, a variety of benzyl alcohols has been efficiently converted to aldehydes under mild conditions. Most reactions are complete within 30 min and the catalyst exhibi...
Mono-alkylation of cyanoimide at a molybdenum(IV) diphosphinic center by alkyl ...
Alegria, Elisabete; Guedes Da Silva, M. Fátima C.; Kuznetsov, Maxim L.; Martins, Luisa; Pombeiro, ArmandoTreatment of trans-[Mo(NCN)(2)(dppe)(2)] with alkyl halides (RX) affords the alkylated cyanoimidocomplexes trans-[Mo(NCN)(NCNR)(dppe)(2)]X [R = Me, X = I (1); R = Et, X = I (2); R = Pr, X = I (3); R = Pr-i, X = I (4); R = CH2Ph, X = Br (5); R = CH2C6H4NO2-4, X = Br (6)], while its reaction with the trimethyloxonium salt [Me3O][BF4] affords trans-[Mo(NCN)(NCNMe)(dppe)(2)][BF4] (7). The reactions are accelerated ...
Cobalt complexes with pyrazole ligands as catalyst precursors for the peroxidat...
Silva, Telma F. S.; Martins, Luisa; Guedes Da Silva, M. Fátima C.; Kuznetsov, Maxim L.; Fernandes, Alexandra R.; Silva, Ana; Pan, Chun-Jern; Lee, Jyh-Fu[CoCl(-Cl)(Hpz(Ph))(3)](2) (1) and [CoCl2(Hpz(Ph))(4)] (2) were obtained by reaction of CoCl2 with HC(pz(Ph))(3) and Hpz(Ph), respectively (Hpz(Ph)=3-phenylpyrazole). The compounds were isolated as air-stable solids and fully characterized by IR and far-IR spectroscopy, MS(ESI+/-), elemental analysis, cyclic voltammetry (CV), controlled potential electrolysis, and single-crystal X-ray diffraction. Electrochemic...