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CCL2 expression predicts clinical outcomes and regulates E-cadherin and angioge...
Silva, Ana Luísa; Barry, Sayka; Lopes-Pinto, Mariana; Joaquim, Rita; Miranda, Catarina; Reis, Fábio; Miranda, Micaella; Matos, Paulo; Suleyman, OnizThe crosstalk between tumour cells and microenvironment components in pituitary neuroendocrine tumours (PitNETs), including chemokines, may impact tumour behaviour and clinical outcomes. CCL2 was previously identified as a key chemokine in PitNETs, but its role remains unknown. We aimed to study the role of CCL2 in defining the phenotype and clinical outcomes of PitNETs and in regulating macrophage chemotaxis, ...
On the Relevance of Soft Tissue Sarcomas Metabolic Landscape Mapping
Esperança-Martins, Miguel; F. Duarte, Iola; Rodrigues, Mara; Soares do Brito, Joaquim; López-Presa, Dolores; Costa, Luís; Fernandes, IsabelSoft tissue sarcomas (STS) prognosis is disappointing, with current treatment strategies being based on a "fit for all" principle and not taking distinct sarcoma subtypes specificities and genetic/metabolic differences into consideration. The paucity of precision therapies in STS reflects the shortage of studies that seek to decipher the sarcomagenesis mechanisms. There is an urge to improve STS diagnosis preci...
Cutaneous Ancient Schwannoma of the Ear
Antunes-Duarte, Sofia; Espinosa Lara, Pablo; Aguado Lobo, Marta; Oliveira, Tiago; Fraga, Ana; López-Presa, Dolores; Soares-de-Almeida, LuísSchwannoma is a benign encapsulated nerve sheath tumor composed of Schwann cells, that may arise anywhere along the course of a nerve. Cutaneous schwannomas, associated with peripheral nerves, usually present as a slow-growing well-circumscribed nodule, localized in the dermis or subcutaneous tissue. They are generally asymptomatic; however, they may become painful by the nervous compression. Since the clinical...
Cervical lymph node schwannoma : an unexpected diagnosis
Silvestre, Catarina Falcão; Almeida-Tavares, Joana; López-Presa, Dolores; Santos, Vanessa Rebelo dos; Rocha, José; Bugalho, Maria JoãoIntroduction: Schwannomas-Schwann cells-originating tumors-may develop in many locations. However, primary schwannomas arising within lymph nodes are extremely rare, with only a few cases described to this date in the English literature. For the intranodal location, most of the cases are described in the abdominal cavity. In these cases, clinicians may consider and check for familial disorders, such as neurofib...