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Presence of new mutations in the TP53 gene in patients with low-risk myelodyspl...
Duarte, Fernando Barroso; Lemes, Romélia Pinheiro Gonçalves; Santos, Talyta Ellen de Jesus dos; Barbosa, Maritza CavalcanteBackground Myelodysplastic syndromes are heterogeneous disorders. Patients with myelodysplastic syndrome disease often have ineffective hematopoiesis, cytopenias, blood cell dysplasia in one or more cell types, and are at high risk for developing acute myeloid leukemia. In myelodysplastic syndrome, mutations of TP53 gene are usually associated with complex karyotype and confer a worse prognosis. In the present ...
Date: 2017
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Origin: Oasisbr