2 documents found, page 1 of 1
Insights into S. aureus-Induced Bone Deformation in a Mouse Model of Chronic Os...
Mandal, Shibarjun; Tannert, Astrid; Ebert, Christina; Guliev, Rustam R.; Ozegowski, Yvonne; Carvalho, Lina; Wildemann, Britt; Eiserloh, SimoneOsteomyelitis is an infection of the bone that is often difficult to treat and causes a significant healthcare burden. Staphylococcus aureus is the most common pathogen causing osteomyelitis. Osteomyelitis mouse models have been established to gain further insights into the pathogenesis and host response. Here, we use an established S. aureus hematogenous osteomyelitis mouse model to investigate morphological t...
Aspergillus fumigatus hijacks human p11 to redirect fungal-containing phagosome...
Jia, Lei-Jie; Rafiq, Muhammad; Radosa, Lukáš; Hortschansky, Peter; Cunha, Cristina; Cseresnyés, Zoltán; Krüger, Thomas; Schmidt, FranziskaThe decision whether endosomes enter the degradative or recycling pathway in mammalian cells is of fundamental importance for pathogen killing, and its malfunctioning has pathological consequences. We discovered that human p11 is a critical factor for this decision. The HscA protein present on the conidial surface of the human-pathogenic fungus Aspergillus fumigatus anchors p11 on conidia-containing phagosomes ...