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Diagnóstico e Seguimento Laboratorial de Doentes com Mieloma Múltiplo
Pires, Ana Marta; Barreto, João Pedro; Caetano, Joana; Rego De Sousa, Maria José; Geraldes, Catarina; Fernandes, Bruno; Coucelo, MargaridaMultiple myeloma is a neoplasm of plasma cells that in most cases is associated with the secretion of monoclonal immunoglobulins and can involve multiple organs. Its timely diagnosis is essential to limit or avoid irreversible damage and dysfunction of target organs. Appropriate initial stratification of patients allows for optimization in the selection and sequence of therapy, as well as proper follow-up durin...
Multiple Myeloma Laboratory Diagnostics Made Simple
Pires, Ana Marta; Barreto, João Pedro; Caetano, Joana; Soares, Maria José; Geraldes, Catarina; Fernandes, Bruno; Coucelo, Margarida; Chacim, SérgioPublisher Copyright: © 2025 by the authors.; Multiple myeloma is a clonal plasma cell malignancy with a highly variable range of clinical manifestations. Over recent decades, substantial progress has been made in laboratory diagnostics, which has deepened our understanding of disease biology, improved risk stratification, and informed treatment strategies. In an era of transformation and innovation, conventiona...
Recomendações do Grupo Português do Mieloma Múltiplo para Tratamento do Mieloma...
João, Cristina; Bergantim, Rui; Santos, Joana; Afonso, Celina; Bernardo, Paulo; Coelho, Henrique; Costa, Carlos; Esteves, Graça; Freitas, José GuilhermeThe treatment of multiple myeloma has profoundly changed with the introduction of several innovative therapies. The optimization of therapeutic sequencing through the combined use of the various drugs developed in recent years and the attention given to the characteristics of patients have allowed the reduction of toxicities and increased survival and quality of life of patients with multiple myeloma. These tre...
Patient-Derived Extracellular Vesicles Proteins as New Biomarkers in Multiple M...
Ferreira, Bruna Velosa; Carneiro, Emilie Arnault; Pestana, Carolina; Barahona, Filipa; Caetano, Joana; Lopes, Raquel; Lúcio, Paulo; Neves, ManuelFunding Information: This research was funded by the Champalimaud Foundation; by the Fundação para a Ciência e Tecnologia – FCT (Research Grant PTDC/MEC-HEM/30315/2017) and by Sociedade Portuguesa de Hematologia -SPH (Initiation to Investigation Grant 2018).; Multiple myeloma (MM) is a hematological malignancy of clonal antibody–secreting plasma cells (PCs). MM diagnosis and risk stratification rely on bone mar...
Measurable Residual Disease Assessment in Multiple Myeloma
Caetano, Joana; Barahona, Filipa; Lúcio, Paulo; João, CristinaPublisher Copyright: © 2022 by the authors.; The introduction of new and more effective therapeutic options for Multiple Myeloma (MM) has significantly deepened and prolonged patients’ remission. As currently used treatment protocols induce high rates of complete responses, Measurable Residual Disease (MRD) assessment has become essential to enhance the evaluation of treatment efficacy. Detection of MRD has imp...