5 documents found, page 1 of 1
Resveratrol and Omega-3 fatty acid-loaded Liposomes as Antibiofilm Strategies a...
Ferraz, MP; Pereira, AB; Terroso, M; Fernando Mendes Monteiro; Lúcio, M; Lopes, CM
Lipid nanocarriers for anti-HIV therapeutics: A focus on physicochemical proper...
Faria, MJ; Lopes, CM; Neves, J; Lúcio, MSince HIV was first identified, and in a relatively short period of time, AIDS has become one of the most devastating infectious diseases of the 21st century. Classical antiretroviral therapies were a major step forward in disease treatment options, significantly improving the survival rates of HIV-infected individuals. Even though these therapies have greatly improved HIV clinical outcomes, antiretrovirals (AR...
A biophysical insight of camptothecin biodistribution: Towards a molecular unde...
Almeida, A; Fernandes, E; Sarmento, B; Lúcio, MCamptothecin (CPT) is a potent anticancer drug, and its putative oral administration is envisioned although difficult due to physiological barriers that must be overcome. A comprehensive biophysical analysis of CPT interaction with biointerface models can be used to predict some pharmacokinetic issues after oral administration of this or other drugs. To that end, different models were used to mimic the phosphol...
Polymeric Electrospun Fibrous Dressings for Topical Co-delivery of Acyclovir an...
Costa, T; Ribeiro, A; Machado, R; Ribeiro, C; Lanceros-Mendez, S; Cavaco-Paulo, A; Almeida, A; Neves, J; Lúcio, M; Viseu, THerpetic infections caused by Herpes simplex virus (HSV) are among the most common human infections, affecting more than two quarters of the world's population. The standard treatment for orofacial herpes is the administration of antiviral drugs, mainly acyclovir (ACV). However, current products are mostly based on semisolid formulations that have limited ability to promote drug skin penetration and tend to lea...
Rational development of liposomal hydrogels: A strategy for topical vaginal ant...
Faria, M; Machado, R; Ribeiro, A; Gonçalves, H; Oliveira, ME; Viseu, T; Neves, J; Lúcio, MHIV/AIDS stands as a global burden, and vaginal microbicides constitute a promising strategy for topical pre-exposure prophylaxis. Preceding the development of a microbicide containing tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC), in silico and in vitro studies were performed to evaluate the physicochemical characteristics of both drugs, and to study their biophysical impact in lipid model system...