41 documents found, page 1 of 5

Monoolein/phytantriol-enriched lipid-based nanocarriers loaded with resveratrol...

Most topical ophthalmic solutions to treat posterior eye disorders demonstrate low therapeutic bioavailability. This results in poor medical outcomes and underlines the need for innovative non-invasive approaches. In this study, lipid-based nanocarriers (LN) of dioctadecyldimethylammonium bromide (DODAB) enriched with monoolein (MO@LN) or phytantriol (PHY@LN) were loaded with resveratrol (RSV-MO@LN/-PHY@LN) and...

Development of biomimetic human nails using electrospun keratin nanofibers and ...

Introduction: Nail infections, particularly onychomycosis, affect approximately 5.5% of the global population, significantly impacting quality of life. Beyond aesthetic concerns, these conditions cause discomfort, functional impairment, and psychological distress. A major challenge in treatment is the low transungual permeability of the nail plate, restricting drug penetration and reducing therapeutic efficacy....

Nanostructured lipid carriers loaded with cannabidiol: A novel antibiofilm appr...

Introduction: Staphylococcus aureus and Staphylococcus epidermidis are major contributors to skin dysbiosis and infections, e.g. folliculitis and intravascular catheter infections, forming biofilms that enhance their resistance to antibiotics and immune responses. Given that antibiotic resistance is a serious challenge, new solutions are constantly being explored. The endocannabinoid system is essential for mai...

Noite europeia dos investigadores em Armamar: uma história contada a várias vozes

A primeira edição da Noite Europeia dos Investigadores em Armamar representou uma iniciativa-piloto de descentralização e democratização da ciência em contexto rural. Integrado no consórcio internacional SCIEVER, o evento envolveu 207 participantes, 29 investigadores e 69 voluntários, através de uma abordagem de cocriação interinstitucional com parceiros locais e nacionais. A iniciativa teve como principais obj...

Noite Europeia dos Investigadores em Armamar: uma história contada a várias vozes

A primeira edição da Noite Europeia dos Investigadores em Ambientes Rurais – Armamar (NEI-Armamar 2023) marcou um passo importante na promoção da cultura científica neste território rural. Este evento integrou o consórcio internacional SCIEVER – “Ciência para todos: sustentabilidade e inclusão” e demonstrou como a ciência pode ser uma ferramenta poderosa para democratizar o conhecimento, fortalecer o desenvolvi...

Noite europeia dos investigadores de Armamar: palco da ciência em ambientes rurais

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A label-free multitechnique approach to characterize the interaction of bioacti...

Extensive research has been conducted on biomimetic interfaces mimicking the complex and diverse microenvironment of cell membranes to gain insights into bioactive compound interactions and membrane biophysics modulation. The present study proposes an innovative approach that combines five prospective label-free methodologies (derivative spectroscopy, synchrotron small- and wide-angle X-Ray scattering, attenuat...

Vitamin D loaded into lipid nanoparticles shows insulinotropic effect in INS-1E...

Increasing evidence suggests a beneficial role of vitamin D (VitD) supplementation in addressing the widespread VitD deficiency, but currently used VitD3 formulations present low bioavailability and toxicity constrains. Hence, poly(L-lactide-co-glycolide) (PLGA) nanoparticles (NPs), solid-lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) were investigated to circumvent these issues. PLGA NPs p...

Noite europeia dos investigadores em Armamar: palco da ciência em ambientes rurais

Grapevine as a natural resource in the cosmetic industry