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Diagnosis and Laboratory Follow-Up of Patients with Multiple Myeloma: Guideline...
Pires, Ana Marta; Barreto, João Pedro; Caetano, Joana; Soares, Maria José; Geraldes, Catarina; Fernandes, Bruno; Coucelo, Margarida; Chacim, SérgioMultiple myeloma is a neoplasm of plasma cells that in most cases is associated with the secretion of monoclonal immunoglobulins and can involve multiple organs. Its timely diagnosis is essential to limit or avoid irreversible damage and dysfunction of target organs. Appropriate initial stratification of patients allows for optimization in the selection and sequence of therapy, as well as proper follow-up durin...
Diagnosis and laboratory follow-up of patients with multiple myeloma: guideline...
Pires, Ana Marta; Barreto, João Pedro; Caetano, Joana; Soares, Maria José; Geraldes, Catarina; Fernandes, Bruno; Coucelo, Margarida; Chacim, SérgioMultiple myeloma is a neoplasm of plasma cells that in most cases is associated with the secretion of monoclonal immunoglobulins and can involve multiple organs. Its timely diagnosis is essential to limit or avoid irreversible damage and dysfunction of target organs. Appropriate initial stratification of patients allows for optimization in the selection and sequence of therapy, as well as proper follow-up durin...
Multiple Myeloma Treatment Guidelines by the Portuguese Group of Multiple Myeloma
João, Cristina; Bergantim, Rui; Santos, Joana; Afonso, Celina; Bernardo, Paulo; Coelho, Henrique; Costa, Carlos; Esteves, Graça; Freitas, José GuilhermeThe treatment of multiple myeloma has profoundly changed with the introduction of several innovative therapies. The optimization of therapeutic sequencing through the combined use of the various drugs developed in recent years and the attention given to the characteristics of patients have allowed the reduction of toxicities and increased survival and quality of life of patients with multiple myeloma. These tre...
A crise humanitária Síria perante o Tribunal Penal Internacional
Lúcio, PauloO presente trabalho tem como objetivo discorrer a respeito da crise humanitária que se faz presente na Síria e de que forma o Tribunal Penal Internacional pode ser vital para a resolução do conflito sírio, tendo em vista que a Corte é uma figura central na defesa dos direitos humanos e na luta contra a impunidade. Antes de dissertar a respeito do caso sírio, pretende-se discutir quanto a maneira que as comunida...
Gamapatias Monoclonais de Significado Indeterminado: Critérios de Diagnóstico e...
Parreira, Joana; Lúcio, Paulo; João, Cristina; Macedo, Ana; Sarmento-Ribeiro, Ana Bela; Geraldes, Catarina; Gonçalves, Cristina; Esteves, GraçaO Grupo Português de Mieloma Múltiplo da Sociedade Portuguesa de Hematologia propôs-se criar um protocolo de avaliação e acompanhamento de doentes com gamapatias monoclonais. O protocolo aqui apresentado, meramente referencial, pretende racionalizar e uniformizar a forma como estes doentes são acompanhados pelos seus médicos assistentes e identifica critérios claros de risco de progressão que justificam a sua r...
Gamapatias Monoclonais de Significado Indeterminado: Critérios de Diagnóstico e...
Parreira, Joana; Lúcio, Paulo; João, Cristina; Macedo, Ana; Sarmento, Ana Bela; Geraldes, Catarina; Gonçalves, Cristina; Esteves, GraçaO Grupo Português de Mieloma Múltiplo da Sociedade Portuguesa de Hematologia propôs-se criar um protocolo de avaliação e acompanhamento de doentes com gamapatias monoclonais. O protocolo aqui apresentado, meramente referencial, pretende racionalizar e uniformizar a forma como estes doentes são acompanhados pelos seus médicos assistentes e identifica critérios claros de risco de progressão que justificam a sua r...
Monoclonal Gammopathies of Indetermined Significance: Diagnosis and Clinical Fo...
Parreira, Joana; Lúcio, Paulo; João, Cristina; Macedo, Ana; Sarmento, Ana Bela; Geraldes, Catarina; Gonçalves, Cristina; Esteves, GraçaThe Portuguese group of multiple myeloma of the Portuguese Society of Hematology proposes a national protocol for diagnosis and clinical follow-up of monoclonal gammopathies. The proposed protocol aims to standardize clinical management of monoclonal gammopathies. Furthermore, it would also define the major risk factors for progression to Multiple Myeloma that require a precocious close articulation between gen...
On CK2 regulation of chronic lymphocytic leukemia cell viability
Martins, Leila; Lúcio, Paulo; Silva, Milene C.; Gameiro, Paula; Silva, Maria G.; Barata, João T.Specific inhibition of signaling elements essential for the viability of B-cell chronic lymphocytic leukemia (CLL) cells offers great promise for the design of more efficient therapies. The protein serine/threonine kinase CK2 is frequently upregulated in cancer, and it is overexpressed and hyperactivated in primary CLL cells from untreated patients. We have shown that inhibition of CK2 induces apoptosis of CLL ...
Economic analysis of rituximab in combination with cyclophosphamide, vincristin...
Braga, Paula; Carvalho, Susana; Gomes, Marília; Guerra, Lurdes; Lúcio, Paulo; Marques, Herlander; Negreiro, Filipa; Pereira, Catarina; Silva, CatarinaEvaluate costs and benefits of rituximab in combination with cyclophosphamide/vincristine/prednisolone chemotherapy regimen (R-CVP), in previously untreated patients with indolent non-Hodgkin lymphoma (NHL), compared to CVP alone from a Portuguese National Health System (NHS) perspective.Cost-effectiveness (Life Years Gained--LYG) and cost-utility analysis (Quality Adjusted Life Years--QALYs) were performed for...
Effects of Delta1 and Jagged1 on early human hematopoiesis: correlation with ex...
Neves, Hélia; Weerkamp, Floor; Gomes, Andreia C; Naber, Brigitta A. E.; Gameiro, Paula; Becker, Jörg D.; Lúcio, Paulo; Clode, NunoIt has been shown that Notch signaling mediated by ligands of both Jagged and Delta families expands the hematopoietic stem cell compartment while blocking or delaying terminal myeloid differentiation. Here we show that Delta1- and Jagged1-expressing stromal cells have distinct effects on the clonogenic and differentiation capacities of human CD34(+) CD38(+) cells. Jagged1 increases the number of bipotent colon...