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Greater expression of the human leukocyte antigen-G (HLA-G) and interleukin-17 ...
Miranda,Lidyane Neves; Reginaldo,Fernanda Priscila Santos; Souza,Daliana Maria Berenice Oliveira; Soares,Christiane Pienna; Silva,Tarsia Giabardo AlvesCONTEXT AND OBJECTIVE:Impaired local cell immunity seems to contribute towards the pathogenesis and progression of cervical intraepithelial neoplasia (CIN), but the underlying molecular mechanisms promoting its progression remain unclear. Identification of new molecular markers for prognosis and diagnosis of early-stage CIN may aid in decreasing the numbers of CIN cases. Several novel immunoregulatory molecules...
HLA class I haplotypes and progression of primary open-angle glaucoma
Zenha,Fábio; Castadelli,Rosistele Maria Oliveira Bezerra; Deghaide,Neifi Hassam Saloum; Donadi,Eduardo Antonio; Rodrigues,Maria de Lourdes VeronesePURPOSE: To verify if patients with primary open-angle glaucoma with HLA class I haplotypes (A9-B12, A2-B40, A1-B8) associated with this disease may have a greater rate of progression than patients who do not present these haplotypes. METHODS: Anatomical and functional glaucoma evaluation (cup-to-disc ratio and visual field) of 25 patients (six of them with one of the haplotypes associated with glaucoma) follow...
Alterations in gene expression profiles correlated with cisplatin cytotoxicity ...
Carminati,Patricia Oliveira; Mello,Stephano Spano; Fachin,Ana Lucia; Junta,Cristina Moraes; Sandrin-Garcia,Paula; Carlotti,Carlos GilbertoGliomas are the most common tumors in the central nervous system, the average survival time of patients with glioblastoma multiforme being about 1 year from diagnosis, in spite of harsh therapy. Aiming to study the transcriptional profiles displayed by glioma cells undergoing cisplatin treatment, gene expression analysis was performed by the cDNA microarray method. Cell survival and apoptosis induction followin...
HLA profile in patients with AIDS and tuberculosis
Figueiredo,José Fernando de Castro; Rodrigues,Maria de Lourdes Veronese; Deghaide,Neifi Hassam Saloum; Donadi,Eduardo AntonioStudies carried out in various populations have reported an association between some HLA specificities and susceptibility to tuberculosis. We investigated the class I and class II HLA profile in Brazilian patients of various ethnic backgrounds who had AIDS and tuberculosis. Twenty-two adult patients with AIDS and tuberculosis (Group I), 103 patients with AIDS without tuberculosis (Group II) and 423 healthy indi...
Effect of metabolic control on the in vitro proliferation of peripheral blood m...
Foss-Freitas,Maria Cristina; Foss,Norma Tiraboschi; Donadi,Eduardo Antonio; Foss,Milton CesarCONTEXT AND OBJECTIVE: Diabetes mellitus is a clinical syndrome that frequently leads to the development of chronic complications and high susceptibility to infections. It is probably due to defective immunological defense, which may be related to metabolic control of the disease. The aim of this study was to evaluate the effect of metabolic control on immune-cell behavior in type 1 and type 2 diabetic patients...
Mortalidade por doenças infecciosas e parasitárias no Município de Teresina-PI ...
Campelo,Viriato; Gonçalves,Maria Alice Guimarães; Donadi,Eduardo AntonioEste estudo relata a mortalidade por doenças infecto-parasitárias em Teresina, nos últimos trinta anos do século XX. Os resultados mostraram que as mortes por doenças infecto-parasitárias diminuíram em coeficientes e em anos potenciais de vida perdidos, e foram superadas pelas mortes relacionadas aos aparelhos circulatório e respiratório, causas externas e neoplasias, entre 1980 e 1990. Em 2000, a faixa etária ...
Immune cellular response to HPV: current concepts
Gonçalves,Maria Alice Guimarães; Donadi,Eduardo AntonioAlthough cellular immunity is essential for the elimination of human papillomavirus (HPV), the mechanisms involved are still poorly understood. We summarize the main mechanisms involved in cellular immune response to infections caused by HPV. Immunotherapies for HPV-related cancers require the disruption of T-cell response control mechanisms, associated with the stimulation of the Th1 cytokine response.