16 documents found, page 1 of 2
Plasma Metabolites Associated with OCT Features of Age-Related Macular Degenera...
Laíns, Inês; Han, Xikun; Gil, João; Providência, Joana; Nigalye, Archana; Alvarez, Rodrigo; Douglas, Vivian Paraskevi; Mendez, Kevin; Katz, RavivPurpose: The most widely used classifications of age-related macular degeneration (AMD) and its severity stages still rely on color fundus photographs (CFPs). However, AMD has a wide phenotypic variability that remains poorly understood and is better characterized by OCT. We and others have shown that patients with AMD have a distinct plasma metabolomic profile compared with controls. However, all studies to da...
Integrating genetics and metabolomics from multi-ethnic and multi-fluid data re...
Han, Xikun; Laíns, Inês; Li, Jun; Li, Jinglun; Chen, Yiheng; Yu, Bing; Qi, Qibin; Boerwinkle, Eric; Kaplan, Robert; Thyagarajan, BharatAge-related macular degeneration (AMD) is a leading cause of blindness in older adults. Investigating shared genetic components between metabolites and AMD can enhance our understanding of its pathogenesis. We conduct metabolite genome-wide association studies (mGWASs) using multi-ethnic genetic and metabolomic data from up to 28,000 participants. With bidirectional Mendelian randomization analysis involving 16...
Urinary Mass Spectrometry Profiles in Age-Related Macular Degeneration
Laíns, Inês; Mendez, Kevin M; Gil, João Q.; Miller, John B; Kelly, Rachel S; Barreto, Patrícia Susana Correia Lopes; Kim, Ivana K; Vavvas, Demetrios GWe and others have shown that patients with different severity stages of age-related macular degeneration (AMD) have distinct plasma metabolomic profiles compared to controls. Urine is a biofluid that can be obtained non-invasively and, in other fields, urine metabolomics has been proposed as a feasible alternative to plasma biomarkers. However, no studies have applied urinary mass spectrometry (MS) metabolomic...
Age-Related Macular Degeneration Staging by Color Fundus Photography vs. Multim...
Farinha, Cláudia; Cachulo, Maria da Luz; Coimbra, Rita; Alves, Dalila; Nunes, Sandrina; Pires, Isabel; Marques, João Pedro; Costa, José; Martins, AméliaEpidemiology of age-related macular degeneration (AMD) is based on staging systems relying on color fundus photography (CFP). We aim to compare AMD staging using CFP to multimodal imaging with optical coherence tomography (OCT), infra-red (IR), and fundus autofluorescence (FAF), in a large cohort from the Epidemiologic AMD Coimbra Eye Study. All imaging exams from the participants of this population-based study...
Baseline predictors for visual acuity loss during observation in diabetic macul...
Busch, Catharina; Okada, Mali; Zur, Dinah; Fraser-Bell, Samantha; Rodríguez-Valdés, Patricio; Cebeci, Zafer; Lupidi, Marco; Fung, Adrian T.Patients with DMO and good baseline VA, managed by observation, are of increased risk for VA loss if DRIL, HRF and EZ disruption are present at baseline. Earlier treatment with anti‐VEGF in these patients may potentially decrease the risk of VA loss at 12 months.
Human Plasma Metabolomics in Age-Related Macular Degeneration: Meta-Analysis of...
Laíns, Inês; Chung, Wonil; Kelly, Rachel S.; Gil, João; Marques, Marco; Barreto, Patrícia; Murta, Joaquim N.; Kim, Ivana K.; Vavvas, Demetrios G.The pathogenesis of age-related macular degeneration (AMD), a leading cause of blindness worldwide, remains only partially understood. This has led to the current lack of accessible and reliable biofluid biomarkers for diagnosis and prognosis, and absence of treatments for dry AMD. This study aimed to assess the plasma metabolomic profiles of AMD and its severity stages with the ultimate goal of contributing to...
Real-world outcomes of observation and treatment in diabetic macular edema with...
Busch, Catharina; Fraser-Bell, Samantha; Zur, Dinah; Rodríguez-Valdés, Patricio J.; Cebeci, Zafer; Lupidi, Marco; Fung, Adrian T.In a real-world setting, the majority of DME patients with very good VA maintained vision at 12 months, regard- less of whether the DME was treated or not. This study supports close observation of eyes with DME and very good VA with consideration of treatment when a one line drop in vision is observed.
Real-world outcomes of non-responding diabetic macular edema treated with conti...
Busch, Catharina; Fraser-Bell, Samantha; Iglicki, Matias; Lupidi, Marco; Couturier, Aude; Chaikitmongkol, Voraporn; Giancipoli, ErmeteThe beneficial effect of an early switch to DEX implant in DME non-responders seen at month 12 was main- tained during the second year. A later switch from anti-VEGF to steroids still provided significant improvement. Eyes continued on anti-VEGF over a period of 24 months maintained vision. A quarter of eyes, which had not improved vision at 12 months, exhibited a delayed response to treatment.
Adherence to a Mediterranean diet, lifestyle and age-related macular degenerati...
Raimundo, Miguel; Mira, Filipe; Cachulo, Maria da Luz; Barreto, Patrícia; Ribeiro, Luísa; Farinha, Cláudia; Laíns, Inês; Nunes, Sandrina; Alves, DalilaPurpose To characterize the lifestyle and nutritional risk profile associated with the Mediterranean diet in a Portuguese population with and without age‐related macular degeneration (AMD). Methods Nested case–control study (n = 883) within the Coimbra Eye Study, including 434 subjects with AMD and 449 age‐ and sex‐matched subjects without AMD. All enrolled subjects underwent a full risk assessment, including l...
Avaliação do Exame Final do Internato Médico em Portugal
Marques, Tiago Reis; Laíns, Inês; Martins, Maria João; Goiana-da-Silva, Francisco; Sampaio, Filipa; Pessanha, Inês; Fernandes, Diogo HipólitoIntrodução: Existe uma elevada heterogeneidade na estrutura da avaliação da formação médica pós-graduada a nível mundial. No entanto, contrastando com outros países, não existem estudos científicos em Portugal que tenham avaliado o modelo da avaliação final da especialidade. O presente estudo pretendeu avaliar a adequação do exame do final da especialidade aos seus propósitos; aí incluída a sua validade enquant...