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A Histone Deacetylase (HDAC) inhibitor with pleiotropic in vitro anti-toxoplasm...

Jublot, Delphine; Cavaillès, Pierre; Kamche, Salima; Francisco, Denise; Fontinha, Diana; Prudêncio, Miguel; Guichou, Jean-Francois; Labesse, Gilles

Toxoplasmosis is a highly prevalent human disease, and virulent strains of this parasite emerge from wild biotopes. Here, we report on the potential of a histone deacetylase (HDAC) inhibitor we previously synthesized, named JF363, to act in vitro against a large panel of Toxoplasma strains, as well as against the liver and blood stages of Plasmodium parasites, the causative agents of malaria. In vivo administra...

Date: 2022   |   Origin: Repositório da Universidade de Lisboa
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