2 documents found, page 1 of 1
The tendon microenvironment: engineered in vitro models to study cellular cross...
Gómez-Florit, Manuel; Labrador-Rached, Claudia J.; Domingues, Rui Miguel Andrade; Gomes, Manuela E.Tendinopathy is a multi-faceted pathology characterized by alterations in tendon microstructure, cellularity and collagen composition. Challenged by the possibility of regenerating pathological or ruptured tendons, the healing mechanisms of this tissue have been widely researched over the past decades. However, so far, most of the cellular players and processes influencing tendon repair remain unknown, which em...
Bioengineered 3D living fibers as in vitro human tissue models of tendon physio...
Calejo, Isabel; Labrador-Rached, Claudia J.; Gomez-Florit, Manuel; Docheva, Denitsa; Reis, R. L.; Domingues, Rui Miguel Andrade; Gomes, Manuela E.Clinically relevant in vitro models of human tissue's health and disease are urgently needed for a better understanding of biological mechanisms essential for the development of novel therapies. Herein, physiological (healthy) and pathological (disease) tendon states are bioengineered by coupling the biological signaling of platelet lysate components with controlled 3D architectures of electrospun microfibers t...