21 documents found, page 1 of 3
Viability assay and DNA double strand break induction in nervous system cells e...
Fernandez-Bertolez, N.; Touzani, A.; Martinez, L.; Méndez, J.; Ramos-Paz, L.; Reis, A.T.; Fraga, S.; Costa, C.; Teixeira, J.P.; Pásaro, E.Cerium dioxide nanoparticles (CeO2 NP) show antioxidant enzyme mimetic properties and free radical scavenging activity. These properties make them a promising material for biomedical applications, but their potential adverse effects are not totally understood yet. Our objective was to assess the biological behaviour of CeO2 NP in human neuronal and glial cells. After carrying out the physical-chemical character...
Utility of salivary leucocytes for biomonitoring of human exposure to nanomater...
Valdiglesias, Vanessa; Fernández-Bertólez, Natália; Touzani, A.; Mendéz, J.; Martinez, L.; Pásaro, E.; Reis, A.T.; Fraga, S.; Teixeira, J.P.; Costa, C.Metal-based nanoparticles (NP) are being increasingly used in a wide variety of applications in consumer products and biomedical practices. As a result, human exposure to these nanomaterials is frequent, becoming a concern to public health. Human salivary leucocytes have been proposed as a proper biological sample for the comet assay, becoming an adequate non-invasive alternative model to evaluate DNA damage. I...
A molecular approach to frailty in older adults
Costa, S.; Costa, C.; Silva, S.; Carvalho, J.; Laffon, B.; Teixeira, João PauloPopulation ageing is transforming economies and societies across the world. The European Commission has appointed Ageing (and Healthy Ageing) one of the main priorities in the next Horizon 2020 Framework Program as part of the Societal Challenges in Europe. The prevention of Frailty in old age is one of the key actions identified. Frailty is a multidimensional syndrome characterized by increased vulnerability a...
In vitro toxicity screening of silica-coated superparamagnetic iron oxide nanop...
Costa, Carla; Brandão, F.; Bessa, M.J.; Costa, S.; Valdiglesias, V.; Kiliç, G.; Fernández-Bertólez, N.; Pásaro, E.; Laffon, B.; Teixeira, João PauloNanotechnology industry is progressing with prospects of substantial benefits to economics and science. Superparamagnetic iron oxide nanoparticles (ION) have been showing excellent magnetic properties, biocompatibility and biodegradability, broadening their potential applications and importance in the biomedical field
Oxidative stress induced by silica-coated iron oxide nanoparticles in SHSY5Y ne...
Kiliç, G.; Costa, C.; Fernández-Bertólez, N.; Costa, S.; Teixeira, Joao Paulo; Pásaro, E.; Laffon, B.; Vdz Park, M.; Valdiglesias, V.Nanotechnology industry is progressing with prospects of substantial benefits to economics and science. Superparamagnetic iron oxide nanoparticles (ION) have been showing excellent magnetic properties, biocompatibility and biodegradability, broadening their potential applications and importance in the biomedical field. Nevertheless, there are increasing concerns as to the potential adverse effects on human heal...
Effects of iron oxide nanoparticles: Cytotoxicity, genotoxicity, developmental ...
Valdiglesias, V.; Kiliç, G.; Costa, C.; Fernández-Bertólez, N; Pásaro, E.; Teixeira, João Paulo; Laffon, B.Iron oxide nanoparticles (ION) with superparamagnetic properties hold great promise for use in various biomedical applications; specific examples include use as contrast agents for magnetic resonance imaging, in targeted drug delivery, and for induced hyperthermia cancer treatments. Increasing potential applications raise concerns over their potential effects on human health. Nevertheless, very little is curren...
Silica-coated iron oxide nanoparticles do not induce DNA double strand breaks o...
Sánchez-Flores, M.; Kiliç, G.; Costa, C.; Fernández-Bertólez, N.; Costa, S.; Teixeira, João Paulo; Pásaro, E.; Valdiglesias, V.; Laffon, B.Since increasing biomedical applications, both diagnostic and therapeutic, of ION are being developed, it is crucial to know how they interact with the cellular material and the possible consequences derived for human health.
Is organic farming safer to farmers' health? A comparison between organic and t...
Costa, C.; García-Lestón, J.; Costa, S.; Coelho, P.; Silva, S.; Pingarilho, M.; Valdiglesias, V.; Mattei, F.; Dall'Armi, V.; Bonassi, S.; Laffon, B.Exposure to pesticides is a major public health concern, because of the widespread distribution of these compounds and their possible long term effects. Recently, organic farming has been introduced as a consumer and environmental friendly agricultural system, although little is known about the effects on workers' health. The aim of this work was to evaluate genetic damage and immunological alterations in worke...
Immunological alterations in individuals exposed to metal(loid)s in the Panasqu...
Coelho, P.; García-Lestón, J.; Costa, S.; Costa, C.; Silva, S.; Fuchs, D.; Geisler, S.; Dall'Armi, V.; Zoffoli, R.; Bonassi, S.; Pásaro, E.; Laffon, B.Environmental studies performed in Panasqueira mine area (central Portugal) identified high concentrations of several metal(loid)s in environmental media, and individuals environmentally and occupationally exposed showed higher levels of As, Cr, Mg, Mn, Mo, Pb and Zn in blood, urine, hair and nails when compared to unexposed controls. To evaluate the presence of immunological alterations attributable to environ...
Biomonitoring of several toxic metal(loid)s in different biological matrices fr...
Coelho, P.; Costa, S.; Costa, C.; Silva, S.; Walter, A.; Ranville, J.; Pastorinho, M.R.; Harrington, C.; Taylor, A.; Dall'Armi, V.; Zoffoli, R.In the Panasqueira mine area of central Portugal, some environmental media show higher metal(loid) concentrations when compared with the local geochemical background and the values proposed in the literature for these environmental media. In order to evaluate the effect of the external contamination on selected indexes of internal dose, As, Cd, Cu, Cr, Fe, Hg, Mg, Mn, Mo, Ni, Pb, S, Se, Si, and Zn were quantifi...