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Finerenone, Obesity, and Heart Failure With Mildly Reduced/Preserved Ejection F...
Butt, Jawad H.; Henderson, Alasdair D.; Jhund, Pardeep S.; Claggett, Brian L.; Desai, Akshay S.; Lay-Flurrie, James; Viswanathan, PrabhakarPublisher Copyright: © 2025 The Authors; Background: Obesity is associated with excessive adipocyte-derived aldosterone secretion, independent of the classical renin-angiotensin-aldosterone cascade, and mineralocorticoid receptor antagonists may be more effective in patients with heart failure (HF) and obesity. Objectives: This study sought to examine the effects of the nonsteroidal mineralocorticoid receptor a...
Finerenone cardiovascular and kidney outcomes by age and sex
Bansal, Shweta; Canziani, Maria E.F.; Birne, Rita; Anker, Stefan D.; Bakris, George L.; Filippatos, Gerasimos; Rossing, Peter; Ruilope, Luis M.Objectives This study aimed to evaluate the efficacy and safety of finerenone, a selective, non-steroidal mineralocorticoid receptor antagonist, on cardiovascular and kidney outcomes by age and/or sex. Design FIDELITY post hoc analysis; median follow-up of 3 years. Setting FIDELITY: a prespecified analysis of the FIDELIO-DKD and FIGARO-DKD trials. Participants Adults with type 2 diabetes and chronic kidney dise...