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Exposure assessment in one central hospital: a multi-approach protocol to achie...

Viegas, Carla; Almeida, Beatriz; Monteiro, Ana; Paciência, Inês; Rufo, João; Aguiar, Lívia; Lage, Bruna; Diogo Gonçalves, Lídia Maria

The bioburden in a Hospital building originates not only from patients, visitors and staff, but is also disseminated by several indoor hospital characteristics and outdoor environmental sources. This study intends to assess the exposure to bioburden in one central hospital with a multi-approach protocol using active and passive sampling methods. The microbial contamination was also characterized through molecul...


Frailty syndrome, biomarkers and environmental factors – A pilot study

Teixeira-Gomes, Armanda; Lage, Bruna; Esteves, Filipa; Sousa, Ana Catarina; Pastorinho, M. Ramiro; Valdiglesias, Vanessa; Costa, Solange; Laffon, Blanca

Frailty is an age-related syndrome expected to increase over the next decades. This syndrome has been identified to be the most common condition leading to disability, institutionalisation and death in the elderly. The aim of this pilot study is to investigate a possible link between frailty status, biomarkers and environmental exposures. A group of 71 older adults (≥65 years old) was engaged in this study. The...


Determining the association between genomic instability and prevalence of frail...

Costa, Solange; Gomes, Armanda Teixeira; Lage, Bruna; Esteves, Filipa; Loureiro, A.; Valdiglesias, Vanessa; Laffon, Blanca; Teixeira, João

The aim of the present study was to investigate the association between genomic instability, via DNA damage and oxidative DNA damage, and the prevalence frailty syndrome in a group of older adults community-dwellers (≥ 65 years old).


Assessment of indoor air exposure at residential homes: Inhalation dose and lun...

Madureira, Joana; Slezakova, Klara; Silva, Ana Inês; Lage, Bruna; Mendes, Ana; Aguiar, Lívia; Pereira, Maria Carmo; Teixeira, João Paulo; Costa, Carla

Accurate assessment of particulate matter (PM) dose and respiratory deposition is essential to better understand the risks of exposure to PM and, consequently, to develop the respective risk-control strategies. In homes, this is especially relevant in regards to ultrafine particles (UFP; <0.1 μm) which origin in these environments is mostly due to indoor sources. Thus, this study aimed to estimate inhalation do...


Frailty syndrome, biomarkers and environmental factors - a pilot study

Teixeira-Gomes, Armanda; Lage, Bruna; Esteves, Filipa; Sousa, Ana Catarina; Pastorinho, M. Ramiro; Valdiglesias, Vanessa; Costa, Solange; Laffon, Blanca

Frailty is an age-related syndrome expected to increase over the next decades. This syndrome has been identified to be the most common condition leading to disability, institutionalisation and death in the elderly. The aim of this pilot study is to investigate a possible link between frailty status, biomarkers and environmental exposures. A group of 71 older adults (≥65 years old) was engaged in this study. The...


Exposure assessment in one central hospital: A multi-approach protocol to achie...

Viegas, Carla; Almeida, Beatriz; Monteiro, Ana; Paciência, Inês; Rufo, João; Aguiar, Lívia; Lage, Bruna; Gonçalves, Lídia; Caetano, Liliana Aranha

The bioburden in a Hospital building originates not only from patients, visitors and staff, but is also disseminated by several indoor hospital characteristics and outdoor environmental sources. This study intends to assess the exposure to bioburden in one central Hospital with a multi-approach protocol using active and passive sampling methods. The microbial contamination was also characterized through molecul...


Occupational exposure to endotoxins: forklift drivers

Costa-Pereira, Cristiana; Lage, Bruna; Viegas, Carla; Teixeira, João Paulo

Many studies have already associated endotoxin exposure, especially in workplaces, to airways disease, yet threshold limit values have not been set, nor a standardized procedure for the analysis of endotoxin levels. Inhaled endotoxins may cause bronchial asthma and may increase the allergic response in hypersensitive people. Endotoxins are biologically active lipopolysaccharides (LPSs) produced by the most exte...


Exposure assessment in one central hospital: A multi-approach protocol to achie...

Viegas, Carla; Almeida, Beatriz; Monteiro, Ana; Paciência, Inês; Rufo, João; Aguiar, Lívia; Lage, Bruna; Diogo Gonçalves, Lídia Maria

The bioburden in a Hospital building originates not only from patients, visitors and staff, but is also disseminated by several indoor hospital characteristics and outdoor environmental sources. This study intends to assess the exposure to bioburden in one central Hospital with a multi-approach protocol using active and passive sampling methods. The microbial contamination was also characterized through molecul...


Endotoxin levels in forklift’s filters and the importance of maintenance enforc...

Pereira, Cristiana Costa; Lage, Bruna; Teixeira, João Paulo; Viegas, Carla

Many studies have already linked endotoxin exposure, especially in workplaces, to airways disease, yet threshold limit values have not been set, nor a standardized procedure for the analysis of endotoxin levels. Inhaled endotoxins may cause bronchial asthma and may increase the allergic response in hypersensitive people. Endotoxins are biologically active lipopolysaccharides (LPSs) produced by the most external...


Life-course exposure and its influence on frailty syndrome

Lage, Bruna

One area of health concern is reducing the burden of environmentally induced disease in populations that may be more susceptible to the effects of exposures to contaminants. The potential to reduce the prevalence of some major diseases is driving research to understand the totality of exposures over the course of our lifetimes. Older adults are well-recognized susceptible subpopulation. Health status in older a...


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