7 documents found, page 1 of 1
Diketopiperazines and other bioactive compounds from bacterial symbionts of mar...
Santos, J.D.; Vitorino, I.; de la Cruz, M.; Díaz, C.; Cautain, B.; Annang, F.; Pérez-Moreno, G.; Gonzalez, I.; Tormo, J.R.; Martin, J.; Vicente, M.F.Humanity faces great challenges, such as the rise of bacterial antibiotic resistance and cancer incidence. Thus, the discovery of novel therapeutics from underexplored environments, such as marine habitats, is fundamental. In this study, twelve strains from the phylum Firmicutes and thirty-four strains from the phylum Proteobacteria, isolated from marine sponges of the Erylus genus, collected in Portuguese wate...
Alienimonas chondri sp. nov., a novel planctomycete isolated from the biofilm o...
Vitorino, I.; Albuquerque, L.; Wiegand, S.; Kallscheuer, N.; da Costa, M.S.; Lobo-da-Cunha, A.; Jogler, C.; Lage, O.M.The phylum Planctomycetes comprises bacteria with peculiar and very unique characteristics among prokaryotes. In marine environments, macroalgae biofilms are well known for harboring planctomycetal diversity. Here, we describe a novel isolate obtained from the biofilm of the red alga Chondrus crispus collected at a rocky beach in Porto, Portugal. The novel strain LzC2T is motile, rosette-forming with spherical-...
Planctomycetes as a vital constituent of the microbial communities inhabiting d...
Storesund, J.E.; Lanzèn, A.; Nordmann, E.L.; Armo, H.R.; Lage, O.M.; Øvreås, L.Meromictic lakes are permanently stratified lakes that display steep gradients in salinity, oxygen and sulphur compounds tightly linked to bacterial community structure and diversity. Lake Sælenvannet is a meromictic lake located south of Bergen, Norway. The 26 m deep lake is connected to the open sea and permanently stratified into two layers separated by a chemocline. The upper water layer is brackish with ma...
Culturable bacteria from two Portuguese salterns: diversity and bioactive poten...
Almeida, E.; Dias, T.V.; Ferraz, G.; Carvalho, M.F.; Lage, O.M.Salterns are extreme environments, where the high salt concentration is the main limitation to microbial growth, along with solar radiation, temperature and pH. These selective pressures might lead to the acquisition of unique genetic adaptations that can manifest in the production of interesting natural products. The present study aimed at obtaining the culturable microbial diversity from two Portuguese salter...
Pink- and orange-pigmented Planctomycetes produce saproxanthin-type carotenoids...
Kallscheuer, N.; Moreira, C.; Airs, R.; Llewellyn, C.A.; Wiegand, S.; Jogler, C.; Lage, O.M.Planctomycetes are ubiquitous and environmentally important Gram‐negative aquatic bacteria with key roles in global carbon and nitrogen cycles. Many planctomycetal species have a pink or orange colour and have been suggested to produce carotenoids. Potential applications as food colorants or anti‐oxidants have been proposed. Hitherto, the planctomycetal metabolism is largely unexplored and the strain pigmentati...
Current screening methodologies in drug discovery for selected human diseases
Lage, O.M.; Ramos, M.C.; Calisto, R.; Almeida, E.; Vasconcelos, V.; Vicente, F.The increase of many deadly diseases like infections by multidrug-resistant bacteria implies re-inventing the wheel on drug discovery. A better comprehension of the metabolisms and regulation of diseases, the increase in knowledge based on the study of disease-born microorganisms’ genomes, the development of more representative disease models and improvement of techniques, technologies, and computation applied ...
Planctomycetes attached to algal surfaces: Insight into their genomes
Faria, M.; Bordin, N.; Kizina, J.; Harder, J.; Devos, D.; Lage, O.M.Planctomycetes are bacteria with complex molecular and cellular biology. They have large genomes, some over 7 Mb, and complex life cycles that include motile cells and sessile cells. Some live on the complex biofilm of macroalgae. Factors governing their life in this environment were investigated at the genomic level. We analyzed the genomes of three planctomycetes isolated from algal surfaces. The genomes were...