9 documents found, page 1 of 1
Bioactivities and extract dereplication of actinomycetales isolated from marine...
Santos, J.D.; Vitorino, I.; De La Cruz, M.; Díaz, C.; Cautain, B.; Annang, F.; Pérez-Moreno, G.; Martinez, I.G.; Tormo, J.R.; Martín, J.M.; Urbatzka, R.In the beginning of the twenty-first century, humanity faces great challenges regarding diseases and health-related quality of life. A drastic rise in bacterial antibiotic resistance, in the number of cancer patients, in the obesity epidemics and in chronic diseases due to life expectation extension are some of these challenges. The discovery of novel therapeutics is fundamental and it may come from underexplor...
Current screening methodologies in drug discovery for selected human diseases
Lage O.M.; Ramos M.C.; Calisto R.; Almeida E.; Vasconcelos V.; Vicente F.The increase of many deadly diseases like infections by multidrug-resistant bacteria implies re-inventing the wheel on drug discovery. A better comprehension of the metabolisms and regulation of diseases, the increase in knowledge based on the study of disease-born microorganisms’ genomes, the development of more representative disease models and improvement of techniques, technologies, and computation applied ...
Planctomycetes attached to algal surfaces: Insight into their genomes
Faria M.; Bordin N.; Kizina J.; Harder J.; Devos D.; Lage O.M.Planctomycetes are bacteria with complex molecular and cellular biology. They have large genomes, some over 7 Mb, and complex life cycles that include motile cells and sessile cells. Some live on the complex biofilm of macroalgae. Factors governing their life in this environment were investigated at the genomic level. We analyzed the genomes of three planctomycetes isolated from algal surfaces. The genomes were...
Adequacy of planctomycetes as supplementary food source for Daphnia magna
Marinho M.C.; Lage O.M.; Catita J.; Antunes S.C.The nutritional quality of daphnids diet can influence their growth, reproduction and survival. In aquatic ecosystems, bacteria can contribute significantly to Daphnia diet by supporting, for instances, their high needs for phosphorus. The laboratory feeding of the model organisms Daphnia spp. is algal based, but should be improved to allow their better performance. The aim of this study was to evaluate the pot...
Introduction to papers from the third meeting on the Planctomycetes-Verrucomicr...
Lage O.M.; Devos D.P.[No abstract available]
Mariniblastus fucicola gen. nov., sp. nov. a novel planctomycete associated wit...
Lage O.M.; Albuquerque L.; Lobo-da Cunha A.; da Costa M.S.One strain of a novel genus and species of the order Planctomycetes, designated FC18T, was isolated from the epiphytic community of Fucusspiralis. This strain was non-pigmented in medium M13 but was slightly pink pigmented on medium M14, containing four-fold the levels of glucose, peptone and yeast extract of M13. The organism was primarily spherical, with unicellular non-motile forms and rosettes. The optimal ...
Epiphytic Planctomycetes communities associated with three main groups of macro...
Bondoso J.; Godoy-Vitorino F.; Balagué V.; Gasol J.M.; Harder J.; Lage O.M.Planctomycetes, a unique group of widespread and understudied bacteria, are known to be associated with macroalgae. The temporal dynamics and the host-specific association of planctomycetal communities on Fucus spiralis, Ulva sp. and Chondrus crispus from two locations in the North Coast of Portugal were assessed both by denaturing gradient gel electrophoresis with group-specific primers and 16S rDNA amplicon l...
Planctomycetes as novel source of bioactive molecules
Graça A.P.; Calisto R.; Lage O.M.Marine environments are a fruitful source of bioactive compounds some of which are the newest leading drugs in medicinal therapeutics. Of particular importance are organisms like sponges and macroalgae and their associated microbiome. Planctomycetes, abundant in macroalgae biofilms, are promising producers of bioactive compounds since they share characteristics, like large genomes and complex life cycles, with ...
Feasibility of planctomycetes as a nutritional or supplementary food source for...
Antunes S.C.; Almeida R.A.; Carvalho T.; Lage O.M.Daphnia magna is widely used as a standard organism in ecotoxicology assays. It plays a key role in energy transfer in freshwater food webs as a primary consumer, grazing on microalgae, yeast and bacteria. Daphnids are commonly reared in the laboratory using microalgae cultures but alternative or complementary sources are important to reduce the dependency on a single food source. The role played in nature by p...