6 documents found, page 1 of 1
An Injectable Thermoreversible Hydrogel Loaded with ManNAc for GNE Myopathy
Violante, Cristiana; Marques-Da-Silva, Dorinda; Videira, Paula Alexandra; Lagoa, RicardoFunding Information: This research was funded by FCT/MCTES (PIDDAC, Portugal) under the programmatic projects UIDB/50020/2020, UIDP/50020/2020 and LA/P/0140/2020; and by the European Commission through GLYCOTwinning (Grant Agreement: 101079417), and Horizon 2020 research and innovation programme under the EJPRD COFUND-EJP N 825575 (EJPRD/0001/2020). Publisher Copyright: © 2025 IEEE.; GNE myopathy (GNEM) is a ra...
Cardiolipin Membranes Promote Cytochrome c Transformation of Polycyclic Aromati...
Lopes, João; Marques-da-Silva, Dorinda; Videira, Paula A.; Samhan-Arias, Alejandro K.; Lagoa, RicardoThe catalytic properties of cytochrome c (Cc) have captured great interest in respect to mitochondrial physiology and apoptosis, and hold potential for novel enzymatic bioremediation systems. Nevertheless, its contribution to the metabolism of environmental toxicants remains unstudied. Human exposure to polycyclic aromatic hydrocarbons (PAHs) has been associated with impactful diseases, and animal models have u...
Regulation of Staphylococcus aureus Virulence and Application of Nanotherapeuti...
Arunachalam, Kannappan; Pandurangan, Poonguzhali; Shi, Chunlei; Lagoa, RicardoFunding Information: The authors gratefully acknowledge financial support from the Science and Technology Commission of Shanghai Municipality of China (Grant No. 21N31900200) and Natural Science Foundation of China (Grant Nos. 32001798, 31972169). Publisher Copyright: © 2023 by the authors.; Staphylococcus aureus is a versatile pathogen known to cause hospital- and community-acquired, foodborne, and zoonotic in...
Removal of Hydrophobic Organic Pollutants and Copper by Alginate-Based and Poly...
Marques-da-Silva, Dorinda; Lopes, João M.; Correia, Iris; Silva, João S.; Lagoa, RicardoPublisher Copyright: © 2022 by the authors.; Organic pollutants (OPs) and heavy metals are environmental toxicants associated with great concerns. Decontamination processes are urgent for both, and the possibility to achieve their simultaneous removal from polluted waters is highly interesting. Additionally, in many cases, the effect of organic matter in the removal process is overlooked and must be considered....
Misuse of Cardiac Lipid upon Exposure to Toxic Trace Elements—A Focused Review
Renu, Kaviyarasi; Mukherjee, Anirban Goutam; Wanjari, Uddesh Ramesh; Vinayagam, Sathishkumar; Veeraraghavan, Vishnu Priya; Vellingiri, BalachandarPublisher Copyright: © 2022 by the authors.; Heavy metals and metalloids like cadmium, arsenic, mercury, and lead are frequently found in the soil, water, food, and atmosphere; trace amounts can cause serious health issues to the human organism. These toxic trace elements (TTE) affect almost all the organs, mainly the heart, kidney, liver, lungs, and the nervous system, through increased free radical formation,...
An electronic questionnaire for liver assessment in congenital disorders of gly...
Marques-da-Silva, Dorinda; Francisco, Rita; dos Reis Ferreira, Vanessa; Forbat, Liz; Lagoa, Ricardo; Videira, Paula A.; Witters, Peter; Jaeken, JaakDorinda Marques-da-Silva acknowledges the support from the Rare Disease Foundation’s microgrant and ‘Liliana Scientific Scholarship’; Rita Francisco acknowledges Fundação para a Ciência e Tecnologia for the grant SFRH/BD/124326/2016 awarded to her.; Congenital disorders of glycosylation (CDG) are ultra-rare diseases showing a great phenotypic diversity ranging from mono-to multi-organ/multisystem involvement. L...