3 documents found, page 1 of 1
(−)-α-Bisabolol inhibits preferentially electromechanical coupling on rat isola...
Siqueira, Rodrigo José Bezerra de; Ribeiro-Filho, Helder Veras; Freire, R. S.; Freire, W. B. S.; Vasconcelos-Silva, A. A.; Soares, M. A.; Lahlou, SaadPrevious findings enable us to hypothesize that (−)-α-bisabolol acts as inhibitor of voltage-dependent Ca2+ channels in smooth muscle. The current studywas aimed at consolidating such hypothesis through the recording of isometric tension, measurement of intracellular Ca2+ as well as discovery of channel target using in silico analysis. In rat aortic rings, (−)-α-bisabolol (1–1000 μM) relaxed KCl- and phenylephr...
Linalool-rich rosewood oil induces vago-vagal bradycardic and depressor reflex ...
Siqueira, Rodrigo José de; Rodrigues, Karilane Maria Silvino; Silva, Moisés Tolentino Bento da; Correia Junior, Carlos Antônio BarrosCardiovascular effects of the linalool-rich essential oil of Aniba rosaeodora (here named as EOAR) in normotensive rats were investigated. In anesthetized rats, intravenous (i.v.) injection of EOAR induced dosedependent biphasic hypotension and bradycardia. Emphasis was given to the first phase (phase 1) of the cardiovascular effects, which is rapid (onset time of 1–3 s) and not observed in animals submitted to...
Mechanisms underlying the cardiovascular effects of a labdenic diterpene isolat...
Lahlou, Saad; Correia Junior, Carlos Antônio de Barros; Santos, Márcio Vasconcelos dos; David, Jorge Mauricio; David, Juceni Pereira de LimaRESTRITO; Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2012-07-03T15:02:01Z No. of bitstreams: 1 AA.pdf: 226361 bytes, checksum: ed917aff58751bf94ff7f571e987446c (MD5); Made available in DSpace on 2012-07-03T15:02:01Z (GMT). No. of bitstreams: 1 AA.pdf: 226361 bytes, checksum: ed917aff58751bf94ff7f571e987446c (MD5) Previous issue date: 2006; Cardiovascular effects of Labd-8 (17)-en-15-oic acid (...