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Pathophysiology of aniridia-associated keratopathy: developmental aspects and u...

Latta, L.; Figueiredo, F. C.; Ashery-Padan, R.; Collinson, J. M.; Daniels, J.; Ferrari, S.; Szentmáry, N.; Solá, Susana; Shalom-Feuerstein, R.; Lako, M.

Aniridia, a rare congenital disease, is often characterized by a progressive, pronounced limbal insufficiency and ocular surface pathology termed aniridia-associated keratopathy (AAK). Due to the characteristics of AAK and its bilateral nature, clinical management is challenging and complicated by the multiple coexisting ocular and systemic morbidities in aniridia. Although it is primarily assumed that AAK orig...


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