3 documents found, page 1 of 1
Molecular alterations of KIT oncogene in gliomas
Gomes, Ana L.; Reis-Filho, Jorge S.; Lopes, José M.; Martinho, Olga; Lambros, Maryou B. K.; Martins, Albino; Schmitt, Fernando; Pardal, FernandoGliomas are the most common and devastating primary brain tumours. Despite therapeutic advances, the majority of gliomas do not respond either to chemo or radiotherapy. KIT, a class III receptor tyrosine kinase (RTK), is frequently involved in tumourigenic processes. Currently, KIT constitutes an attractive therapeutic target. In the present study we assessed the frequency of KIT overexpression in gliomas and i...
Caveolin 1 is overexpressed and amplified in a subset of basal-like and metapla...
Savage, Kay; Lambros, Maryou B. K.; Robertson, David; Jones, Robin L.; Jones, Chris; Mackay, Alan; James, Michelle; Hornick, Jason L.The distribution and significance of caveolin 1 (CAV1) expression in different breast cell types and role in breast carcinogenesis remain poorly understood. Both tumor-suppressive and oncogenic roles have been proposed for this protein. The aims of this study were to characterize the distribution of CAV1 in normal breast, benign breast lesions, breast cancer precursors, and metaplastic breast carcinomas; to ass...
Metaplastic breast carcinomas exhibit EGFR, but not HER2, gene amplification an...
Reis-Filho, Jorge S.; Milanezi, Maria Fernanda Grillo; Carvalho, Silvia; Simpson, Pete T.; Steele, Dawn; Savage, Kay; Lambros, Maryou B. K.Metaplastic breast carcinomas constitute a heterogeneous group of neoplasms, accounting for less than 1% of all invasive mammary carcinomas. Approximately 70-80% of metaplastic breast carcinomas overexpress the epidermal growth factor receptor (EGFR). Human epidermal growth factor receptor (HER)2 and EGFR have attracted much attention in the medical literature over the past few years owing to the fact that huma...