4 documents found, page 1 of 1
Bidirectional flow of action potentials in axons drives activity dynamics in ne...
Mateus, J. C.; Lopes, C. D. F.; Aroso, M.; Costa, A. R.; Gerós, A.; Meneses, J.; Faria, P.; Neto, E.; Lamghari, M.; Sousa, M. M.; Aguiar, PObjective. Recent technological advances are revealing the complex physiology of the axon and challenging long-standing assumptions. Namely, while most action potential (AP) initiation occurs at the axon initial segment in central nervous system neurons, initiation in distal parts of the axon has been reported to occur in both physiological and pathological conditions. The functional role of these ectopic APs, ...
INJECTABLE HYBRID SYSTEM FOR STRONTIUM LOCAL DELIVERY TO PROMOTE BONE REGENERATION
Lourenço, A.H.; Machado, A,; Neves, N.; Alexandre, N.; Lamghari, M.; Barrias, C.C.; Barbosa, M.A.; Ribeiro, C,In bone tissue regeneration strategies, injectable bone substitutes are very attractive since they can be applied with minimally invasive surgical procedures and can perfectly fill irregular defects created in cases of trauma, infection or tumor resection. These materials must combine adequate mechanical properties with the ability to induce new bone formation. Incorporating strontium (Sr) in bone substitute bi...
IN VIVO STUDY OF THE EFFECT OF A STRONTIUM-‐RICH INJECTABLE SYSTEM ON BONE REG...
Machado, C.; Lourenço, A.H.; Neves, N.; Alexandre, Nuno; Lamghari, M.; Cabral, A.T.; Barbosa, M.A.; Ribeiro, C.C.Bone has the capacity to regenerate as part of the repair process,being newly formed boné indistinguishable from the adjacente uninjured bone. However,there are cases in which boné regeneration is required in large quantity, beyond the normal potential for self-‐healing, such as for lesions caused by trauma, infection, tumour resection or cases in which the regenerative process is compromised such as avascular...
Protein matrices for improved wound healing : elastase inhibition by a syntheti...
Vasconcelos, Andreia; Pêgo, A. P.; Lamghari, M.; Henriques, L.; Paulo, Artur CavacoThe unique properties of silk fibroin were combined with keratin to develop new wound-dressing materials. Silk fibroin/keratin (SF/K) films were prepared to reduce high levels of elastase found on chronic wounds. This improved biological function was achieved by the incorporation of a small peptide synthesized based on the reactive-site loop of the Bowman−Birk Inhibitor (BBI) protein. In vitro degradation and r...