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Updating the OMERACT filter: implications of filter 2.0 to select outcome instr...

Tugwell, P; Boers, M; D'Agostino, MA; Beaton, D; Boonen, A; Bingham, CO; Choy, E; Conaghan, PG; Dougados, M; Duarte, C; Furst, DE; Guillemin, F

OBJECTIVE: The Outcome Measures in Rheumatology (OMERACT) Filter provides guidelines for the development and validation of outcome measures for use in clinical research. The "Truth" section of the OMERACT Filter requires that criteria be met to demonstrate that the outcome instrument meets the criteria for content, face, and construct validity. METHODS: Discussion groups critically reviewed a variety of ways in...


Applying science in practice: the optimization of biological therapy in rheumat...

Ramiro, S; Machado, P; Singh, JA; Landewé, RB; Pereira da Silva, JA

Most authorities recommend starting biological agents upon failure of at least one disease-modifying agent in patients with rheumatoid arthritis. However, owing to the absence of head-to-head studies, there is little guidance about which biological to select. Still, the practicing clinician has to decide. This review explores the application of published evidence to practice, discussing the goals of treatment, ...


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