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Hydroalcoholic extract of Brazilian green propolis modulates inflammatory proce...
Miranda, Marina Barcelos de; Lanna, Mariana Ferreira; Nascimento, Ana Luiza Barros; Paula, Carmen Aparecida de; Silva, Marcelo EustáquioThe occurrence of inflammation and protein malnutrition is an aggravating risk factor for morbidity and mortality in the clinical setting. The green propolis, a natural product made by Apis mellifera bees from Baccharis dracunculifolia resin, has therapeutic potential to modulate chronic inflammation. However, its effect on inflammation in an impaired nutritional status is not known. The aim of this study was t...
Multicomponent LBSap vaccine displays immunological and parasitological profile...
Mendonça, Ludmila Zanandreis de; Resende, Lucilene Aparecida; Lanna, Mariana Ferreira; Soares, Rodrigo Dian de Oliveira Aguiar; Roatt, Bruno MendesBackground: In past years, many researchers have sought canine visceral leishmaniasis (CVL) prevention through the characterization of Leishmania antigens as vaccine candidates. Despite these efforts, there is still no efficient vaccine for CVL control. Methods: In the present study, we performed a pre-clinical vaccine trial using BALB/c mice to compare the effects of the multicomponent LBSap vaccine with those...
Estudo morfométrico do desenvolvimento folicular ovariano de camundongas albino...
Lanna, Mariana FerreiraCoordenação de Aperfeiçoamento de Pessoal de Nível Superior; The histomorphometric analysis is one of the main tools in the study of ovarian follicular development, mainly in animal experimentation. However, the results reviewed in the literature are contradictory, especially regarding to the quantification of ovarian follicles. This work was conducted with 29 virgin mice, among pre-pubertal, young and adult (3...
Cytokine and nitric oxide patterns in dogs immunized with LBSap vaccine, before...
Resende, Lucilene Aparecida; Roatt, Bruno Mendes; Soares, Rodrigo Dian de Oliveira Aguiar; Viana, Kelvinson Fernandes; Mendonça, Ludmila Zanandreis deIn the studies presented here, dogs were vaccinated against Leishmania (Leishmania) cha-gasi challenge infection using a preparation of Leishmania braziliensis promastigote proteinsand saponin as adjuvant (LBSap). Vaccination with LBSap induced a prominent type 1immune response that was characterized by increased levels of interleukin (IL-) 12 andinterferon gamma (IFN- _) production by peripheral blood mononucl...