3 documents found, page 1 of 1
Efficacy and safety of erenumab in adults with medication overuse headache: fin...
Tepper, Stewart J.; Dodick, David W.; Lanteri-Minet, Michel; Dolezil, David; Gil-Gouveia, Raquel; Lucas, Christian; Piasecka-Stryczynska, KarolinaBackground: Erenumab-induced medication overuse headache (MOH) remission in participants with chronic migraine (CM) in a prospective, Phase 4, randomized, placebo-controlled trial with an open-label treatment period (OLTP). We present 1-year results from the combined double-blind treatment period (DBTP) and OLTP for the stratified nonopioid cohort. Methods: Participants with CM-MOH were randomized 1:1:1 to subc...
Hallmarks of primary headache: part 3 - cluster headache
Coppola, Gianluca; Arruda, Marco Antônio; Ashina, Messoud; Barloese, Mads; Belin, Andrea Carmine; Bottiroli, Sara; Chowdhury, DebashishBackground: Cluster headache (CH) is a rare primary headache disorder characterized by recurrent episodes of strictly unilateral excruciating pain accompanied by trigemino-autonomic signs, which significantly impacts the quality of life, social interactions, and occupational functioning of those who are affected. To promote a better understanding of this disabling condition and to foster research on the topic, ...
Efficacy and safety of erenumab for nonopioid medication overuse headache in ch...
Tepper, Stewart J.; Dodick, David W.; Lanteri-Minet, Michel; Dolezil, David; Gil-Gouveia, Raquel; Lucas, Christian; Piasecka-Stryczynska, KarolinaIMPORTANCE Patients with chronic migraine and medication overuse headaches (CM-MOH) represent a particularly burdened subpopulation. This trial provides first, to our knowledge, American Academy of Neurology class I evidence for a preventive therapy in CM-MOH. OBJECTIVE To assess erenumab efficacy and safety in patients with nonopioid CM-MOH. DESIGN, SETTINGS, AND PARTICIPANTS This randomized, double-blind, par...