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Coupling the antimalarial cell penetrating peptide TP10 to classical antimalari...
Aguiar, L; Biosca, A; Lantero, E; Gut, J; Vale, N; Rosenthal, PJ; Nogueira, F; Andreu, D; Fernàndez-Busquets, X; Gomes, PRecently, we disclosed primaquine cell penetrating peptide conjugates that were more potent than parent primaquine against liver stage Plasmodium parasites and non-toxic to hepatocytes. The same strategy was now applied to the blood-stage antimalarial chloroquine, using a wide set of peptides, including TP10, a cell penetrating peptide with intrinsic antiplasmodial activity. Chloroquine-TP10 conjugates displayi...
Date: 2019
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Origin: Repositório Aberto da Universidade do Porto