3 documents found, page 1 of 1
AZD-7648, a DNA-PK Inhibitor, Induces DNA Damage, Apoptosis, and Cell Cycle Arr...
Lapa, Beatriz Santos; Costa, Maria Inês; Figueiredo, Diana; Jorge, Joana; Alves, Raquel; Monteiro, Ana Raquel; Serambeque, Beatriz; Laranjo, MafaldaThe non-homologous end joining pathway is vital for repairing DNA double-strand breaks (DSB), with DNA-dependent protein kinase (DNA-PK) playing a critical role. Altered DNA damage response (DDR) in chronic (CML) and acute myeloid leukemia (AML) offers potential therapeutic opportunities. We studied the therapeutic potential of AZD-7648 (DNA-PK inhibitor) in CML and AML cell lines. This study used two CML (K-56...
Zinc Prevents DNA Damage in Normal Cells but Shows Genotoxic and Cytotoxic Effe...
Costa, Maria Inês; Lapa, Beatriz Santos; Jorge, Joana; Alves, Raquel; Carreira, Isabel Marques; Sarmento-Ribeiro, Ana Bela; Gonçalves, Ana CristinaGenomic instability is prevented by the DNA damage response (DDR). Micronutrients, like zinc (Zn), are cofactors of DDR proteins, and micronutrient deficiencies have been related to increased cancer risk. Acute myeloid leukemia (AML) patients commonly present Zn deficiency. Moreover, reports point to DDR defects in AML. We studied the effects of Zn in DDR modulation in AML. Cell lines of AML (HEL) and normal hu...
Metabolism as a therapeutic target in acute myeloid leukemic – Glycolysis or Ox...
Lapa, Beatriz SantosDissertação de Mestrado em Investigação Biomédica apresentada à Faculdade de Medicina; As células tumorais necessitam de alterar o seu metabolismo de forma a conseguirem manter taxas elevadas de crescimento e proliferação. Uma das alterações metabólicas mais frequentes nas células tumorais é o efeito de Warburg. Nesta situação, as células tumorais alteram o seu metabolismo de oxidação fosforilativa (OXPHOS) par...