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Cannabidiol for the treatment of crack-cocaine craving: an exploratory double-b...
Meneses-Gaya,Carolina de; Crippa,José A.; Hallak,Jaime E.; Miguel,André Q.; Laranjeira,Ronaldo; Bressan,Rodrigo A.; Zuardi,Antonio W.; Lacerda,Acioly L.Objective: To assess the efficacy of cannabidiol (CBD) in the management of crack-cocaine craving and the treatment of frequent withdrawal symptoms. Methods: Thirty-one men with a diagnosis of crack-cocaine dependence were enrolled in a randomized, double-blind, placebo-controlled trial. We applied neuropsychological tests and assessed craving intensity, anxiety and depression symptoms, and substance use patter...
Estupros no Brasil e relações com o consumo de álcool: estimativas baseadas em ...
Massaro,Luciana Teixeira dos Santos; Adesse,Leila; Laranjeira,Ronaldo; Caetano,Raul; Madruga,Clarice S.Com base na análise dos dados de corte transversal provenientes do Segundo Levantamento Nacional de Álcool e Drogas realizado em 2012, utilizando-se uma amostra probabilística estratificada por conglomerado representativa da população brasileira, este estudo apresenta as prevalências de estupro e analisa a relação deste evento com o consumo de álcool. Foram considerados 1.918 homens e 2.365 mulheres, totalizand...
Alcohol misuse among women in Brazil: recent trends and associations with unpro...
Massaro,Luciana T.S.; Abdalla,Renata R.; Laranjeira,Ronaldo; Caetano,Raul; Pinsky,Ilana; Madruga,Clarice S.Objective: This study compared the rates of binge drinking (BD) and alcohol use disorder (AUD) reported for 2006 with those reported for 2012, exploring their associations with unprotected sex, early pregnancy, and abortion in a representative sample of women in Brazilian households. Methods: This was a descriptive analysis of data from a cross-sectional study involving randomized multistage cluster sampling of...
Genome-wide DNA methylation profile in the peripheral blood of cocaine and crac...
Camilo,Caroline; Maschietto,Mariana; Vieira,Henrique C.; Tahira,Ana C.; Gouveia,Gisele R.; Feio dos Santos,Ana C.; Negrão,André B.; Ribeiro,MarceloObjective: Cocaine use disorders (CUDs) represent a major public health problem in many countries. To better understand the interaction between the environmental modulations and phenotype, the aim of the present study was to investigate the DNA methylation pattern of CUD patients, who had concomitant cocaine and crack dependence, and healthy controls. Methods: We studied DNA methylation profiles in the peripher...
Preliminary results from Brazil's first recovery housing program
do Carmo,Dhione Almeida; Palma,Sonia Maria Motta; Ribeiro,Ariadne; Trevizol,Alisson Paulino; Brietzke,Elisa; Abdalla,Renata RigacciAbstract Introduction: The recovery housing (RH) program was initiated in São Paulo with the objective of providing treatment for substance use disorders and addressing users’ housing and employment problems. The purpose of this study was to describe the model based on its first 11 months of operation, it was launched in June 2016 in Brazil. Method: We carried out a retrospective analysis of the records of all ...
Abortion and sex-related conditions in substance-dependent Brazilian patients
Diehl,Alessandra; Pillon,Sandra Cristina; Santos,Manoel Antonio dos; Laranjeira,RonaldoAbstract: Abortion is a very sensitive issue with relevance to public health; however few clinical or population-based studies have examined induced abortion among drug users. The study aims to evaluate the prevalence of induced abortion and sex-related conditions in an inpatient drug user sample. A cross-sectional design study was conducted in an inpatient addiction treatment unit in São Paulo, Brazil, with a ...
Brazilian cross-cultural adaptation and validation of the List of Threatening E...
Abreu,Patrícia B. de; Cogo-Moreira,Hugo; Pose,Regina A.; Laranjeira,Ronaldo; Caetano,Raul; Gaya,Carolina M.; Madruga,Clarice S.Objective: To perform a construct validation of the List of Threatening Events Questionnaire (LTE-Q), as well as convergence validation by identifying its association with drug use in a sample of the Brazilian population. Methods: This is a secondary analysis of the Second Brazilian National Alcohol and Drugs Survey (II BNADS), which used a cross-cultural adaptation of the LTE-Q in a probabilistic sample of 4,6...
Amphetamine-type stimulant use and conditional paths of consumption: data from ...
Massaro,Luciana T.S.; Abdalla,Renata R.; Laranjeira,Ronaldo; Caetano,Raul; Pinsky,Ilana; Madruga,Clarice S.Objective: The aim of this study was to estimate nationally representative prevalence rates of amphetamine-type stimulant (ATS) use and to identify consumption-associated factors, proposing a conditional model of direct and indirect consumption paths. Method: Using data from the Second Brazilian National Alcohol and Drugs Survey, this cross-sectional study analyzed a subsample of 3,828 participants between 15 a...
Intimate partner violence trends in Brazil: data from two waves of the Brazilia...
Ally,Elizabeth Z.; Laranjeira,Ronaldo; Viana,Maria C.; Pinsky,Ilana; Caetano,Raul; Mitsuhiro,Sandro; Madruga,Clarice S.Objective: To compare intimate partner violence (IPV) prevalence rates in 2006 and 2012 in a nationally representative household sample in Brazil. The associations between IPV and substance use were also investigated. Methods: IPV was assessed using the Conflict Tactic Scale-R in two waves (2006/2012) of the Brazilian Alcohol and Drugs Survey. Weighted prevalence rates and adjusted logistic regression models we...
Suicide among physicians in the state of São Paulo, Brazil, across one decade
Palhares-Alves,Hamer N.; Palhares,Daniel M.; Laranjeira,Ronaldo; Nogueira-Martins,Luiz A.; Sanchez,Zila M.Objective:To describe mortality by suicide among physicians in the state of São Paulo, Brazil, between 2000 and 2009.Methods:Secondary analysis of government mortality data. The variable of interest was “underlying cause of death”, specifically deaths classified by the ICD-10 as intentional self-harm (X60 to X84).Results:The analyses examined 2,297 declarations of death, among which suicide accounted for 50 cas...