61 documents found, page 1 of 7
TRAP sequence – A case of successful conservative management
Varejão, Ana; Dória, Mariana; Laranjo, Mafalda; Soares, Fátima; Sarmento Gonçalves, InêsTwin reversed arterial perfusion (TRAP) is a rare sequence that complicates monochorionic multiple pregnancies. This condition affects both fetuses - the acardiac twin and the pump twin. This report presents the case of a monochorionic multiple pregnancy complicated by TRAP diagnosed in the first trimester. After clarifying the couple and multidisciplinary discussion, conservative management was chosen because...
PRES in eclampsia – Two clinical cases
Varejão, Ana; Bem, Pedro; Laranjo, Mafalda; Sá Couto, AdelinaEclampsia is the convulsive manifestation of hypertensive disorders of pregnancy. Posterior reversible encephalopathy syndrome (PRES) is characterized by a variety of neurological signs and symptoms as well as characteristic neuroimaging findings reflecting subcortical vasogenic edema, particularly in the posterior regions and typically reversible within days or weeks. The authors present two clinical cases of ...
Influence of Aldehyde Dehydrogenase Inhibition on Stemness of Endometrial Cance...
Serambeque, Beatriz; Mestre, Catarina; Barros, Gabriela; Marques Teixo, Ricardo Jorge; Marto, Carlos Miguel; Gonçalves, Ana CristinaPublisher Copyright: © 2024 by the authors.; Endometrial cancer is one of the most common gynaecological malignancies. Although often diagnosed at an early stage, there is a subset of patients with recurrent and metastatic disease for whom current treatments are not effective. Cancer stem cells (CSCs) play a pivotal role in triggering tumorigenesis, disease progression, recurrence, and metastasis, as high aldeh...
TRAP sequence – A case of successful conservative management
Varejão, Ana Mesquita; Dória, Mariana; Laranjo, Mafalda; Soares, Fátima; Gonçalves, Inês SarmentoTwin reversed arterial perfusion (TRAP) is a rare sequence that complicates monochorionic multiple pregnancies. This condition affects both fetuses - the acardiac twin and the pump twin. This report presents the case of a monochorionic multiple pregnancy complicated by TRAP diagnosed in the firsttrimester. After clarifying the couple and multidisciplinary discussion, conservative management was chosen because n...
Effect of varying functional monomers in experimental self-adhesive composites:...
Ferreira, Marta Nunes; Neves Dos Santos, Marta; Fernandes, Inês; Marto, Carlos Miguel; Laranjo, Mafalda; Silva, Diana; Serro, Ana PaulaThe aim was to evaluate the effects of adding different functional monomers to experimental self-adhesive composites (SACs) on polymerization kinetics, cell metabolic activity, and sealing ability. SACs were formulated using urethane dimethacrylate as the base monomer and triethylene glycol dimethacrylate. Additionally, 10 wt.% of distinct functional monomers were added - 10-methacryloyloxydecyl dihydrogen phos...
AZD-7648, a DNA-PK Inhibitor, Induces DNA Damage, Apoptosis, and Cell Cycle Arr...
Lapa, Beatriz Santos; Costa, Maria Inês; Figueiredo, Diana; Jorge, Joana; Alves, Raquel; Monteiro, Ana Raquel; Serambeque, Beatriz; Laranjo, MafaldaThe non-homologous end joining pathway is vital for repairing DNA double-strand breaks (DSB), with DNA-dependent protein kinase (DNA-PK) playing a critical role. Altered DNA damage response (DDR) in chronic (CML) and acute myeloid leukemia (AML) offers potential therapeutic opportunities. We studied the therapeutic potential of AZD-7648 (DNA-PK inhibitor) in CML and AML cell lines. This study used two CML (K-56...
Eyelid Reconstruction and Infraorbital Repair Using a Mustardé Flap Technique i...
Guerra Guimarães, Tarcísio; Menezes Cardoso, Karla; Pacheco, Magda; Olivério, Pedro; Faim, Susana; Marto, Carlos Miguel; Alexandre, NunoThis case report describes a 5-year-old dog with a defect in the right eyelid, absence of orbicularis musculature, and absence of cutaneous tissue in the infraorbital region, submitted to the Mustardé flap technique. A large rotational flap was performed, including a cartilage graft from the outer ear, to correct the defect in the lower eyelid and infraorbital region. Also, euryblepharon correction of the upper...
Evaluation of eye melanoma treatments in rabbits: A systematic review.
Guimarâes, Tarcísio Guerra; Marto, Carlos Miguel; Cardoso, Karla Menezes; Alexandre, Nuno; Botelho, Maria Filomena; Laranjo, MafaldaGuimarães, T. G., Marto, C. M., Cardoso, K. M., Alexandre, N., Botelho, M. F., & Laranjo, M. (2022). Evaluation of eye melanoma treatments in rabbits: A systematic review [Review]. Laboratory Animals, 56(2), 119-134. https://doi.org/10.1177/00236772211039333
Localização subcelular do novo fotossensibilizador em células do melanoma ocula...
Guimarães, Tarcísio Guerra; Menezes Cardoso, Karla; Marto, Carlos Miguel; Teixo, Ricardo; Serambeque, Beatriz; Pereira, Nélson; Piñeiro, MartaIntrodução: O melanoma ocular é o objetivo de várias investigações em medicina e medicina veterinária devido à baixa taxa de resposta aos tratamentos conservadores convencionais1. A terapia fotodinâmica (PDT) é uma terapia mais conservadora para os tecidos não neoplásicos, que induz e ativa as vias de morte celular nos tecidos neoplásicos alvo2,3. O fotossensibilizador, luz e oxigenio são os três componentes vi...
OCULAR MELANOMA IN DOGS AND CATS: EPIDEMIOLOGICAL SURVEY IN PORTUGA
Guimarães, Tarcísio Guerra; Mamede, Fábio; Cardoso, Karla Menezes; Marto, Carlos; Caramelo, Francisco; Tasso, Gláuber; Andrade, Arthur; Alexandre, NunoPurpose: The epidemiology of ocular melanoma in dogs and cats in Portugal was assessed. Methods: Data collection was carried out through the distribution of an online questionnaire for veterinarians in Portugal. The survey covered the year 2018 and was made available for responses from 2019-2020. Results: 47 responses were obtained, representing 5.7% of there turn to the survey. A total of 32.61% of the profess...