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Case Report: Mutation in NPPA Gene As a Cause of Fibrotic Atrial Myopathy

Silva Cunha, P; Antunes, D; Laranjo, S; Coutinho, A; Abecasis, J; Oliveira, MM

Early-onset atrial fibrillation (AF) can be the manifestation of a genetic atrial myopathy. However, specific genetic identification of a mutation causing atrial fibrosis is rare. We report a case of a young patient with an asymptomatic AF, diagnosed during a routine examination. The cardiac MRI revealed extensive atrial fibrosis and the electrophysiology study showed extensive areas of low voltage. The genetic...


Validation of a Heart Failure Risk Score in a Cohort of Cardiac Resynchronizati...

Cardoso, I; Cunha, P; Laranjo, S; Grazina, A; Viegas, J; Portugal, G; Valente, B; Lousinha, A; Brás, P; Brás, M; Cruz Ferreira, R; Oliveira, M

The heart failure risk status (HFRS) is a validated dynamic tool for risk score prediction, based on the TriageHF™ algorithm (Medtronic, Minneapolis, MN, USA), for the occurrence of a heart failure (HF) event in the 30 days following a remote monitoring (RM) transmission. The aim of this study was to evaluate the accuracy of the HFRS in predicting an unplanned hospital admission due to HF decompensation in a re...


Clinical Outcome of a Single Procedure Cryoballoon Ablation for the Treatment o...

Silva Cunha, P; Fonseca, P; Laranjo, S; Montenegro Sá, F; Valente, B; Portugal, G; Gonçalves, H; Nogueira da Silva, M; Brandão, L; Oliveira, MM

Background: Cryoballoon ablation (CBA) for pulmonary vein isolation (PVI) has been growing as an alternative technique, not only in patients with paroxysmal atrial fibrillation (PAF) but also in persistent atrial fibrillation (AF). Cryoballoon ablation has demonstrated encouraging acute and mid-term results. However, data on long-term follow-up of CB-based PVI are scarce. Objective: We sought to examine efficac...


Protocol-Based Cardiotoxicity Monitoring in Hydroxychloroquine Medicated COVID-...

Hormigo, I; Milheiro Silva, T; Laranjo, S; Trigo, C; Garcia, AM; Gouveia, C; Brito, MJ

Introduction/objectives: By May 2020, SARS-CoV-2 had caused more than 400 000 deaths worldwide. Initially, hydroxychloroquine was a treatment option for COVID-19. More recent studies have questioned its safety and efficacy and, until stronger evidence is available, it was suspended from therapy protocols. We describe our experience treating COVID-19 Portuguese pediatric patients with hydroxychloroquine, having ...



The Atrium in Atrial Fibrillation - A Clinical Review on How to Manage Atrial F...

Silva Cunha, P; Laranjo, S; Heijman, J; Oliveira, MM

Atrial fibrillation (AF) is the most common sustained arrhythmia in the population and is associated with a significant clinical and economic burden. Rigorous assessment of the presence and degree of an atrial arrhythmic substrate is essential for determining treatment options, predicting long-term success after catheter ablation, and as a substrate critical in the pathophysiology of atrial thrombogenesis. Cath...



Lockdown Measures for COVID-19 Outbreak and Variation in Physical Activity in P...

Silva Cunha, P; Laranjo, S; Lourenço, A; Rodrigues, L; Cardoso, I; Portugal, G; Valente, B; Delgado, AS; Cruz Ferreira, R; Abreu, A; Oliveira, M

Aims: The present study analysed the patterns of physical activity pre-, during and post-lockdown measures for COVID-19 pandemic in patients with chronic heart failure (CHF) and cardiac implantable electronic devices (CIED) under remote monitoring (RM), and assessed the physical activity patterns during these periods. Methods: The raw data from 95 patients with CHF (age 67,7 ± 15,1 years, 71,5% male) correspond...


Amiodarone-Induced Thyrotoxicosis in a Pediatric Patient: A Rare and Demanding ...

Oliveira, S; Marques, B; Laranjo, S; Lopes, L

Thyroid dysfunction is one of the most common adverse effects of amiodarone therapy, ranging from subclinical changes to overt clinical thyrotoxicosis (AIT) and/or hypothyroidism. Due to its heterogeneity, AIT lasts as a defiant entity, leading to a thorny treatment course, particularly in pediatrics. AIT can be classified as either type 1, type 2 or mixed form based on its pathophysiology. Differentiating betw...


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