10 documents found, page 1 of 1
Estimation of Missing Baseline Serum Creatinine for Acute Kidney Injury Diagnos...
Laszczyńska, O; Severo, M; Correia, S; Azevedo, AIntroduction: In hospitalized patients, information on preadmission kidney function is often missing, impeding timely and accurate acute kidney injury (AKI) detection and affecting results of AKI-related studies. Objective: In this study, we provided estimates of preadmission serum creatinine (SCr), based on a multivariate linear regression (Model 1) and random forest model (Model 2) built with different parame...
Definition of baseline renal function in hospitalised patients with multiple pr...
Laszczyńska, O; Severo, M; Azevedo, AAim. With the use of a joint model (JM) we investigated how different definitions of baseline serum creatinine (SCr) would affect the association between an acute increase in inpatients' SCr and 30-day mortality and whether this effect depends on premorbid SCr trajectory. Methods. This was a retrospective study including adult patients admitted to a tertiary acute-care hospital in Porto, Portugal, between Janua...
Serum creatinine trajectories in real-world hospitalized patients: clinical con...
Laszczyńska, O; Severo, M; Mascarenhas, J; Paiva, JA; Azevedo, AFluctuations in serum creatinine (SCr) during hospitalization may provide additional prognostic value beyond baseline renal function. This study aimed to identify groups of patients with distinct creatinine trajectories over hospital stay and assess them in terms of clinical characteristics and short-term mortality. This retrospective study included 35 853 unique adult admissions to a tertiary referral center b...
Patient and system delays in the treatment of acute coronary syndrome
Viana, M; Laszczyńska, O; Araújo, C; Borges, A; Barros, V; Ribeiro, AI; Dias, P; Maciel, MJ; Moreira, I; Lunet, N; Azevedo, AIntroduction Early reperfusion for patients with ST-segment elevation myocardial infarction (STEMI) is indicated by the European Society of Cardiology, while a timely invasive strategy is recommended for patients with high-risk and intermediate-risk non-ST-elevation acute coronary syndromes (NSTE-ACS). This study aims to assess patient and system delays according to diagnosis and risk profile, and to identify p...
Conversion methods for modified Jaffe reaction assays of serum creatinine
Laszczyńska, O; Azevedo, A; Ferreira-Almeida, M; Guimarães, JT; Severo, MBackground: Modifications in Jaffe serum creatinine (sCr) assays question the suitability of the results for direct comparison. Methods: sCr in adult in-patients was routinely measured either by SRM 909-standardized/noncompensated (method A) or isotope dilution mass spectrometry traceable/compensated method (reference). We converted values by method A into values by the reference using a formula provided by the...
Quality of Care and 30-day Mortality of Women and Men With Acute Myocardial Inf...
Araújo, C; Laszczyńska, O; Viana, M; Dias, P; Maciel, MJ; Moreira, I; Azevedo, AIntroduction and objectives Despite increased awareness of sex disparities in care and outcomes of acute myocardial infarction (AMI), there appears to have been no consistent attenuation of these differences over the last decade. We investigated differences by sex in management and 30-day mortality using the European Society of Cardiology Acute Cardiovascular Care Association quality indicators (QIs) for AMI. M...
Early prediction of treatment failure in severe community-acquired pneumonia: T...
Pereira, JM; Laszczyńska, O; Azevedo, A; Basílio, C; Sousa-Dias, C; Mergulhão, P; Paiva, JAPurpose To identify a single/panel of biomarkers and to provide a point score that, after 48 h of treatment, could early predict treatment failure at fifth day of Intensive Care Unit (ICU) stay in severe community-acquired pneumonia (SCAP) patients. Materials and methods Single-center, prospective cohort study of 107 ICU patients with SCAP. Primary outcome included death or absence of improvement in Sequential ...
Sex-related inequalities in management of patients with acute coronary syndrome...
Araújo, C; Pereira, M; Laszczyńska, O; Dias, P; Azevedo, ABackground: Real‐world data from different levels of hospital specialisation would help to understand if differences in management between women and men with acute coronary syndrome (ACS) are still a priority target. We aimed to identify sex inequalities in management of patients with different types of ACS. Methods: We analysed 1757 patients with a non‐ST‐elevation ACS (NSTEACS) and 1184 with ST elevation myoc...
Prognostic Effect of the Dose of Loop Diuretic Over Five Years in Chronic Heart...
Laszczyńska, O; Severo, M; Friões, F; Lourenço, P; Silva, S; Bettencourt, P; Lunet, N; Azevedo, ABackground: High diuretic doses in chronic heart failure (HF) are potentially deleterious. We assessed the effect of dynamic furosemide dose on all-cause mortality among HF ambulatory patients. Methods and Results: A cohort of 560 ambulatory patients from an outpatient clinic specialized in HF, with median age 70 years, 67% male, and 89% with moderate-severely reduced ejection fraction, was retrospectively foll...
Missed Opportunities in Symptomatic Patients before a First Acute Coronary Synd...
Araújo, C; Laszczyńska, O; Viana, M; Dias, P; Maciel, MJ; Azevedo, AOBJECTIVES: The aim of this study was to assess the proportion of patients with a first episode of acute coronary syndrome (ACS) reporting preceding chest pain, having previously sought medical care and undergone the performance of exams, and to identify the determinants of seeking medical advice and undergoing electrocardiogram (ECG). METHODS: Within a cohort study, 690 patients with a first episode of ACS wer...