8 documents found, page 1 of 1
Prognostic Effect of Renal Function in Ambulatory Patients With Heart Failure a...
Mascarenhas, J; Laszczynska, O; Severo, M; Friões, F; Alvelos, M; Bettencourt, P; Pimenta, J; Azevedo, ABackground: Chronic kidney disease is a frequent comorbidity in heart failure (HF), associated with increased mortality. The impact of temporal evolution of kidney function in HF prognosis is largely unknown. We evaluated the effect of renal function over time in all-cause mortality among ambulatory patients with HF. Methods: We retrospectively analyzed data from 560 patients with HF with left ventricular systo...
Disability-adjusted life years lost due to ischemic heart disease in mainland P...
Henriques, A; Araújo, C; Viana, M; Laszczynska, O; Pereira, M; Bennett, K; Lunet, N; Azevedo, AIntrodução e objetivos: A carga de doença atribuível à doença isquémica do coração (DIC), nomeadamente possíveis diferenças regionais, deve orientar políticas de saúde. Pretendemos estimar a carga de doença atribuível a DIC em Portugal continental em 2013, através do cálculo dos anos de vida saudável perdidos (DALY) e comparar estas estimativas entre regiões. Métodos: Calcularam-se os anos de vida perdidos (YLL...
Electronic Medical Record-Based Predictive Model for Acute Kidney Injury in an ...
Laszczynska, O; Severo, M; Azevedo, APatients with acute kidney injury (AKI) are at risk for increased morbidity and mortality. Lack of specific treatment has meant that efforts have focused on early diagnosis and timely treatment. Advanced algorithms for clinical assistance including AKI prediction models have potential to provide accurate risk estimates. In this project, we aim to provide a clinical decision supporting system (CDSS) based on a s...
Trends in pharmacological therapy following an acute coronary syndrome in Portu...
Pereira, M; Lopes-Conceicao, L; Bennett, K; Dias, P; Laszczynska, O; Lunet, N; Azevedo, AAIMS: To assess time trends in the use of main drug classes for secondary prevention, during hospitalization and at hospital discharge, following an acute coronary syndrome, in Portugal, using a systematic review. METHODS: We searched PubMed, from inception until 2012, to identify studies reporting the proportion of acute coronary syndrome patients treated with main pharmacological therapy. We used linear regre...
Validity of the Seattle Heart Failure Model for prognosis in a population at lo...
Laszczynska, O; Severo, M; Frioes, F; Lourenco, P; Silva, S; Bettencourt, P; Lunet, N; Azevedo, AAIM: Validation of the Seattle Heart Failure Model (SHFM) for predicting the risk of death in a population different than the derivation cohort. METHODS: In a retrospective analysis of a cohort of chronic heart failure patients with left ventricular systolic dysfunction, consecutively referred between 2000 and 2011, we computed the score, according to characteristics at referral. We compared the observed risk o...
Prognostic value of sST2 added to BNP in acute heart failure with preserved or ...
Friões, F; Lourenço, P; Laszczynska, O; Almeida, PB; Guimarães, JT; Januzzi, JL; Azevedo, A; Bettencourt, PBackground: Natriuretic peptides and suppression of tumorigenicity 2 (ST2) represent two different physiopathological pathways. We evaluated the prognostic accuracy and complementarity of B-type natriuretic peptide (BNP) and soluble ST2 (sST2) plasma levels at discharge from a hospital admission for acute heart failure, both in patients with preserved (HFpEF) and depressed (HFrEF) systolic function. Methods and...
Medication adherence to specific drug classes in chronic heart failure
Viana, M; Laszczynska, O; Mendes, S; Lourenço, P; Bettencourt, P; Lunet, N; Azevedo, ABACKGROUND: Adherence to medication is crucial to improve clinical outcomes in patients with heart failure (HF). However, at least 1 out of 4 patients is nonadherent to his or her medication. Several studies have quantified medication adherence in HF patients, monitoring only 1 drug with the Medication Event Monitoring System (MEMS). Some authors have argued that monitoring 1 drug reflects the whole adherence b...
Prognostic value of worsening renal function in outpatients with chronic heart ...
Pimentel, R; Couto, M; Laszczynska, O; Frioes, F; Bettencourt, P; Azevedo, AIntroduction and objectives: Renal function impairment predicts poor survival in heart failure. Attention has recently shifted to worsening renal function, based mostly on serum creatinine and estimated glomerular filtration rate. We assessed the prognostic effect of worsening renal function in ambulatory heart failure patients. Methods: Data from 306 ambulatory patients were abstracted from medical files. Wors...