5 documents found, page 1 of 1
Phagosomal removal of fungal melanin reprograms macrophage metabolism to promot...
Gonçalves, Samuel M.; Duarte-Oliveira, Cláudio; Campos, Cláudia F.; Aimanianda, Vishukumar; ter Horst, Rob; Leite, Luis; Mercier, ToineIn response to infection, macrophages adapt their metabolism rapidly to enhance glycolysis and fuel specialized antimicrobial effector functions. Here we show that fungal melanin is an essential molecule required for the metabolic rewiring of macrophages during infection with the fungal pathogen Aspergillus fumigatus. Using pharmacological and genetic tools, we reveal a molecular link between calcium sequestrat...
Definition of the anti-inflammatory oligosaccharides derived from the galactosa...
Gressler, Markus; Heddergott, Christoph; N'Go, Inés C.; Renga, Giorgia; Oikonomou, Vasilis; Moretti, Silvia; Coddeville, Bernadette; Gaifem, JoanaGalactosaminogalactan (GAG) is an insoluble aminosugar polymer produced by Aspergillus fumigatus and has anti-inflammatory properties. Here, the minimum glycosidic sequences required for the induction of IL-1Ra by peripheral blood mononuclear cells (PBMCs) was investigated. Using chemical degradation of native GAG to isolate soluble oligomers, we have found that the de-N-acetylation of galactosamine residues an...
Recognition of DHN-melanin by a C-type lectin receptor is required for immunity...
Stappers, Mark H. T.; Clark, Alexandra E.; Aimanianda, Vishukumar; Bidula, Stefan; Reid, Delyth M.; Asamaphan, Patawee; Hardison, Sarah E.Resistance to infection is critically dependent on the ability of pattern recognition receptors to recognize microbial invasion and induce protective immune responses. One such family of receptors are the C-type lectins, which are central to antifungal immunity. These receptors activate key effector mechanisms upon recognition of conserved fungal cell-wall carbohydrates. However, several other immunologically a...
CD4+ T cell vaccination overcomes defective cross-presentation of fungal antige...
Luca, Antonella De; Iannitti, Rossana G.; Bozza, Silvia; Beau, Remi; Casagrande, Andrea; D’Angelo, Carmen; Moretti, Silvia; Cunha, CristinaAspergillus fumigatus is a model fungal pathogen and a common cause of infection in individuals with the primary immunodeficiency chronic granulomatous disease (CGD). Although primarily considered a deficiency of innate immunity, CGD is also linked to dysfunctional T cell reactivity. Both CD4+ and CD8+ T cells mediate vaccine-induced protection from experimental aspergillosis, but the molecular mechanisms leadi...
TLR3 essentially promotes protective class I–restricted memory CD8+ T-cell resp...
Carvalho, Agostinho; De Luca, Antonella; Bozza, Silvia; Cunha, Cristina; D’Angelo, Carmen; Moretti, Silvia; Perruccio, Katia; Iannitti, Rossana G.Aspergillus fumigatus is a model fungal pathogen and a common cause of severe infections and diseases. CD8+ T cells are present in the human and murine T-cell repertoire to the fungus. However, CD8+ T-cell function in infection and the molecular mechanisms that control their priming and differentiation into effector and memory cells in vivo remain elusive. In the present study, we report that both CD4+ and CD8+...