2 documents found, page 1 of 1
PLGA nanoparticles double-decorated with a TAT peptide and folic acid to target...
Andrade, Stéphanie; Ramalho, Maria J.; Santos, João; Santos, Sílvio Roberto Branco; Melo, Luís Daniel Rodrigues; Guimarães, Nuno; Ferraz, Maria P.Treating bacterial infections has become increasingly difficult due to the rise in antibiotic-resistant bacterial strains. Strategies involving the targeted delivery of antibiotics have been proposed to minimize the administered antibiotic doses. This study aims to develop the first double-modified nanovehicle capable of increasing bacterial membranes permeability while specifically targeting Staphylococcus aur...
Lytic bacteriophages against multidrug-resistant Staphylococcus aureus, Enteroc...
Barros, Joana; Melo, Luís Daniel Rodrigues; Poeta, Patrícia; Igrejas, Gilberto; Ferraz, Maria P.; Azeredo, Joana; Monteiro, Fernando J.Orthopedic implant-associated infections are a devastating complication with significant impact on patients and on healthcare systems. The aims of this work were to describe the patterns of antibiotic resistance, pathogenicity and virulence of clinical bacterial strains isolated from orthopedic implant-associated infections and to further isolate and characterize bacteriophages that are efficient in controlling...