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Oral glucose tolerance testing at 1 h and 2 h: relationship with glucose and ca...

Guerreiro, V; Maia, I; Neves, JS; Salazar, D; Ferreira, MJ; Mendonça, F; Silva, MM; Borges-Canha, M; Viana, S; Costa, C; Pedro, J; Varela, A; Lau, E

Background: One hour plasma glucose concentration (1hPG) during an oral glucose tolerance test (OGTT) may be an alternative to 2-h plasma glucose concentration (2hPG) in the identification of individuals at increased risk of hyperglycaemia, although its role is not fully understood. Aim: We aim to investigate the relationship of these measures with other glucose parameters, as well as their relationship with ca...


The impact of vitamin d in non-alcoholic fatty liver disease: A cross-sectional...

Borges-Canha, M; Neves, JS; Mendonça, F; Silva, MM; Costa, C; Cabral, PM; Guerreiro, V; Lourenço, R; Meira, P; Salazar, D; Ferreira, MJ; Pedro, J

Purpose: We aimed to evaluate the association between vitamin D status and hepatic function parameters and scores: Fatty Liver Index (FLI, predictor of hepatic steatosis) and BARD (BMI, AST/ALT ratio and DM, predictor of hepatic fibrosis) in patients with morbid obesity. Patients and Methods: Cross-sectional study including patients with morbid obesity followed in our centre between January 2010 and July 2018. ...


Beta Cell Function as a Baseline Predictor of Weight Loss After Bariatric Surgery

Borges-Canha, M; Neves, JS; Mendonça, F; Silva, MM; Costa, C; M Cabral, P; Guerreiro, V; Lourenço, R; Meira, P; Salazar, D; Ferreira, MJ; Pedro, J

Background: Obesity is a multifactorial disease, which is strongly associated to other metabolic disorders. Bariatric surgery is the most effective treatment of morbid obesity. The role of beta cell function in weight loss after bariatric surgery is uncertain. Aim: To evaluate the association between beta cell function and percentage of total body weight loss (TBWL%) 1, 2, 3, and 4 years after bariatric surgery...


Adequate magnesium level as an associated factor of pre-diabetes and diabetes m...

Guerreiro, V; Maia, I; Neves, JS; Salazar, D; Ferreira, MJ; Mendonça, F; Silva, MM; Viana, S; Costa, C; Pedro, J; Varela, A; Lau, E; Freitas, P

Bariatric surgery (BS) can lead to remission of type 2 diabetes mellitus (T2DM), however, the evidence on the influence of preoperative serum magnesium levels on this reversal is scarce. To study the influence of preoperative serum magnesium levels on the pre-T2DM and T2DM remission one year after BS. Retrospective study carried out among 1656 patients with obesity who underwent BS in the Centro Hospitalar Univ...


Secondary Hyperparathyroidism Among Bariatric Patients: Unraveling the Prevalen...

Mendonça, FM; Neves, JS; Silva, MM; Borges Canha, M; Costa, C; Cabral, PM; Guerreiro, V; Lourenço, R; Meira, P; Correia, Flora; Salazar, D; Pedro, J

Introduction Bariatric surgery (BS) is the most effective therapeutic approach to obesity. It is associated with great gastrointestinal anatomic changes, predisposing the patients to altered nutrient absorption that impacts phosphocalcium metabolism. This study aimed to clarify the prevalence of secondary hyperparathyroidism (SHPT) and its predictors in patients submitted to BS. Methods Retrospective study of 1...


Thyroid Function and the Risk of Non-Alcoholic Fatty Liver Disease in Morbid Ob...

Borges-Canha, M; Neves, JS; Mendonça, F; Silva, MM; Costa, C; Cabral, PM; Guerreiro, V; Lourenço, R; Meira, P; Salazar, D; Ferreira, MJ; Pedro, J

Background: An association between hypothyroidism and the risk of Non-alcoholic Fatty Liver Disease (NAFLD) has been suggested. This association remains to be elucidated in patients with morbid obesity. Aim: To evaluate the association between thyroid function and parameters of liver function and hepatic scores in patients with morbid obesity. Methods: Patients with morbid obesity followed in our center between...


Probiotic ingestion, obesity, and metabolic-related disorders: Results from NHA...

Lau, E; Neves, J; Ferreira-Magalhães, M; Carvalho, D; Freitas, P

Gut microbiota dysbiosis has been recognized as having key importance in obesity- and metabolic-related diseases. Although there is increasing evidence of the potential benefits induced by probiotics in metabolic disturbances, there is a lack of large cross-sectional studies to assess population-based prevalence of probiotic intake and metabolic diseases. Our aim was to evaluate the association of probiotic ing...


HIV-Infected Patients With and Without Lipodystrophy Under Combined Antiretrovi...

Grenha, I; Oliveira, J; Lau, E; Santos, AC; Sarmento, A; Pereira, J; Carvalho, D; Freitas, P

In HIV-infected patients, combined antiretroviral therapy (cART) is associated to adipose tissue redistribution known as lipodystrophy and associated cardiometabolic risk. This study aimed to evaluate the evolution of body composition in HIV-infected patients, with and without lipodystrophy, over 2 yr. We evaluated anthropometric parameters and body composition by whole-body dual-energy X-ray absorptiometry in ...


Effects of bariatric surgery on blood pressure of non-hypertensive obese patients

Neves, J. S; Castro-Oliveira, Sofia; Souteiro, P; Bettencourt-Silva, R; Magalhães, D; Costa, M. M; Saavedra, A; Oliveira, J; Cunha, F; Lau, E


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