4 documents found, page 1 of 1
Consistent Long-Term Therapeutic Efficacy of Human Umbilical Cord Matrix-Derive...
Laundos, TL; Vasques-Nóvoa, F; Gomes, RN; Sampaio-Pinto, V; Cruz, P; Cruz, H; Santos, JM; Barcia, RN; Pinto-do-Ó, P; Nascimento, DSHuman mesenchymal stem cells gather special interest as a universal and feasible add-on therapy for myocardial infarction (MI). In particular, human umbilical cord matrix-derived mesenchymal stromal cells (UCM-MSC) are advantageous since can be easily obtained and display high expansion potential. Using isolation protocols compliant with cell therapy, we previously showed UCM-MSC preserved cardiac function and ...
Neonatal Apex Resection Triggers Cardiomyocyte Proliferation, Neovascularizatio...
Sampaio-Pinto, V; Rodrigues, SC; Laundos, TL; Silva, ED; Vasques-Nóvoa, F; Silva, AC; Cerqueira, R; Resende, TP; Pianca, N; Leite-Moreira, A; D'Uva, GSo far, opposing outcomes have been reported following neonatal apex resection in mice, questioning the validity of this injury model to investigate regenerative mechanisms. We performed a systematic evaluation, up to 180 days after surgery, of the pathophysiological events activated upon apex resection. In response to cardiac injury, we observed increased cardiomyocyte proliferation in remote and apex regions,...
Fibrin functionalization with synthetic adhesive ligands interacting with a6ß1 ...
Silva, J; Bento, AR; Barros, D; Laundos, TL; Sousa, SR; Quelhas, P; Sousa, MM; Pêgo, AP; Amaral, IFTo enhance fibrin hydrogel affinity towards pluripotent stem cell-derived neural stem/progenitor cells (NSPCs) and its capacity to support NSPC migration and neurite extension, we explored the tethering of synthetic peptides engaging integrin a6ß1, a cell receptor enriched in NSPCs. Six a6ß1 integrin ligands were tested for their ability to support integrin a6ß1-mediated adhesion of embryonic stem cell-derived ...
Rotary orbital suspension culture of embryonic stem cell-derived neural stem/pr...
Laundos, TL; Silva, J; Assunção, M; Quelhas, P; Monteiro, C; Oliveira, C; Oliveira, MJ; Pêgo, AP; Amaral, IFEmbryonic stem (ES)-derived neural stem/progenitor cells (ES-NSPCs) constitute a promising cell source for application in cell therapies for the treatment of central nervous system disorders. In this study, a rotary orbital hydrodynamic culture system was applied to single-cell suspensions of ES-NSPCs, to obtain homogeneously-sized ES-NSPC cellular aggregates (neurospheres). Hydrodynamic culture allowed the for...