4 documents found, page 1 of 1
Framework for clinical trials in cerebral small vessel disease (FINESSE)
Markus, Hugh S.; van Der Flier, Wiesje M.; Smith, Eric E.; Bath, Philip; Biessels, Geert Jan; Briceno, Emily; Brodtman, Amy; Chabriat, HuguesImportance: Cerebral small vessel disease (SVD) causes a quarter of strokes and is the most common pathology underlying vascular cognitive impairment and dementia. An important step to developing new treatments is better trial methodology. Disease mechanisms in SVD differ from other stroke etiologies; therefore, treatments need to be evaluated in cohorts in which SVD has been well characterized. Furthermore, SV...
Accelerated decline in quadriceps area and Timed Up and Go test performance are...
Marques, Elisa A.; Elbejjani, Martine; Viana, João L.; Gudnason, Vilmundur; Sigurdsson, Gunnar; Lang, Thomas; Sigurdsson, Sigurdur; Aspelund, ThorThis study aimed to examine whether an accelerated decline in quadriceps cross-sectional area (CSA), attenuation (a surrogate of quality), and strength, as well as lower limb muscular function, are associated with hip fractures in older adults with impaired kidney function.
Associations of Quadriceps Torque Properties with Muscle Size, Attenuation, and...
Frank-Wilson, Andrew W; Chalhoub, Didier; Figueiredo, Pedro; Jónsson, Pálmi V; Siggeirsdóttir, Kristín; Sigurdsson, Sigurdur; Eiriksdottir, GudnyAtrophy and fatty infiltration of muscle with aging are associated with fractures and falls, however, their direct associations with muscle function are not well described. It was hypothesized that participants with lower quadriceps muscle attenuation, area, and greater intramuscular adipose tissue (IMAT) will exhibit slower rates of torque development (RTD) and lower peak knee extension torques.
Associations of 24-hour sleep duration and CT-derived measurements of muscle an...
Marques, Elisa A.; Figueiredo, Pedro; Gudnason, Vilmundur; Lang, Thomas; Sigurdsson, Gunnar; Sigurdsson, Sigurdur; Aspelund, ThorAlthough the importance of sleep on preservation of several physiological functions is well known, the relationship with the two interconnected tissues - muscle and bone is less understood.