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Concept of extremes in vascular aging: from early vascular aging to supernormal...

Laurent, Stephane; Boutouyrie, Pierre; Cunha, Pedro Miguel Guimarães Marques; Lacolley, Patrick; Nilsson, Peter M.

[Excerpt] With advancing age, changes in the arterial wall contribute to what has been called vascular aging, and in some prematurely affected subjects even early vascular aging (EVA).1–5 Several years ago,1 we listed various components of EVA, including arteriosclerosis, atherosclerosis, and excess vasoconstriction, with their clinical expression: arterial stiffening and increased central pulse pressure, carot...


Characteristics of healthy vascular ageing in pooled population-based cohort st...

Nilsson, Peter M.; Laurent, Stephane; Cunha, Pedro Miguel Guimarães Marques; Olsen, Michael H.; Rietzschel, Ernst; Franco, Oscar H.; Ryliškytė, Ligita

Arterial ageing is characterized by increasing arterial stiffness as measured by pulse wave velocity (PWV). This process is enhanced in participants with early vascular ageing (EVA), but slowed in participants with healthy vascular ageing (HVA). We aimed to describe characteristics of EVA and HVA in a transcontinental study including 11 cohorts.


Arterial stiffness and influences of the metabolic syndrome: a cross-countries ...

Scuteri, Angelo; Cunha, Pedro Guimarães; Rosei, E. Agabiti; Bekaert, Sofie; Cockcrofti, John R.; Cotter, Jorge; Cucca, Francesco; De Buyzere, Marc L.

Specific clusters of metabolic syndrome (MetS) components impact differentially on arterial stiffness, indexed as pulse wave velocity (PWV). Of note, in several population-based studies participating in the MARE (Metabolic syndrome and Arteries REsearch) Consortium the occurrence of specific clusters of MetS differed markedly across Europe and the US. The aim of the present study was to investigate whether spec...


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