Encontrados 12 documentos, a visualizar página 1 de 2
Nanoemulsified Butenafine for Enhanced Performance against Experimental Cutaneo...
Bezerra-Souza, Adriana; Jesus, Jéssica A.; Laurenti, Márcia D.; Lalatsa, Aikaterini; Serrano, Dolores R.; Passero, Luiz Felipe D. [UNESP]Made available in DSpace on 2021-06-25T10:58:23Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01; The production of ergosterol lipid involves the activity of different enzymes and is a crucial event for the Leishmania membrane homeostasis. Such enzymes can be blocked by azoles and allylamines drugs, such as the antifungal butenafine chloride. This drug was active on parasites that cause cutaneous an...
Mechanistic insights into the leishmanicidal and bactericidal activities of Bat...
Dematei, Anderson; Nunes, João B.; Moreira, Daniel C.; Jesus, Jéssica A.; Laurenti, Márcia D.; Mengarda, Ana C. A.; Vieira, Maria SilvaSnake venoms are important sources of bioactive molecules, including those with antiparasitic activity. Cathelicidins form a class of such molecules, which are produced by a variety of organisms. Batroxicidin (BatxC) is a cathelicidin found in the venom of the common lancehead (Bothrops atrox). In the present work, BatxC and two synthetic analogues, BatxC(C-2.15Phe) and BatxC(C-2.14Phe)des-Phe1, were assessed f...
Antileishmanial activity and ultrastructural changes of sesquiterpene lactones ...
Caldas, Lhaís Araújo; Yoshinaga, Meire L.; Ferreira, Marcelo J.P.; Lago, João H.G.; de Souza, Adriana B.; Laurenti, Márcia D.Made available in DSpace on 2019-10-06T16:03:52Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-03-01; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Laboratórios de Investigação Médica - Hospital das Clínicas da Faculdade de Medicina da Universidade d...
Effect of phospholipase A2 inhibitors during infection caused by Leishmania (Le...
Bordon, Maria L.A.C. [UNESP]; Laurenti, Márcia D.; Ribeiro, Susan Pereira; Toyama, Marcos H. [UNESP]; Toyama, Daniela de O.Made available in DSpace on 2018-12-11T17:22:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-08-27. Added 1 bitstream(s) on 2021-07-15T15:22:08Z : No. of bitstreams: 1 S1678-91992018000100312.pdf: 922596 bytes, checksum: 18fb86fe456fe9c71e3e438fca44c19d (MD5); Background: Lipid metabolites play an important role in parasite differentiation and virulence. Studies have revealed that Leishmania sp. uses ...
The antifungal compound butenafine eliminates promastigote and amastigote forms...
Bezerra-Souza, Adriana; Yamamoto, Eduardo S.; Laurenti, Márcia D.; Ribeiro, Susan P.; Passero, Luiz Felipe D. [UNESP]Made available in DSpace on 2018-12-11T17:06:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-12-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); The production of ergosterol lipid, important for the Leishmania membrane homeostasis, involves different enzymes. This pathway can be blocked to azoles and allylamines drugs, such as Butenafine. The aim of the present work was to evaluate t...
Therapeutic effect of ursolic acid in experimental visceral leishmaniasis
Jesus, Jéssica A.; Fragoso, Thais N.; Yamamoto, Eduardo S.; Laurenti, Márcia D.; Silva, Marcelo S.; Ferreira, Aurea F.; Lago, João Henrique G.Made available in DSpace on 2018-12-11T17:08:17Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-04-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Leishmaniasis is an important neglected tropical disease, affecting more than 12 million people worldwide. The available treatments are not well tolerated and present diverse side effects in patients, justifying the search for new therapeuti...
Antileishmanial activity of meroditerpenoids from the macroalgae Cystoseira bac...
Bruno de Sousa, Carolina; Gangadhar, Katkam N.; Morais, Thiago R.; Conserva, Geanne A.A.; Vizetto-Duarte, Catarina; Pereira, Hugo; Laurenti, Márcia D.Made available in DSpace on 2018-12-11T17:09:38Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-03-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); The development of novel drugs for the treatment of leishmaniases continues to be crucial to overcome the severe impacts of these diseases on human and animal health. Seve...
Salivary gland homogenates from wild-caught sand flies Lutzomyia flaviscutellat...
Laurenti, Márcia D.
Proteins of Leishmania (Viannia) shawi confer protection associated with Th1 im...
Laurenti, Márcia D.
Susceptibility of Cebus apella monkey (Primates: Cebidae) to experimental Leish...
Carneiro, Liliane Almeida; Silveira, Fernando Tobias; Campos, Marliane Batista; Brígido, Maria do Carmo de Oliveira; Gomes, Claudia Maria C.In Amazonian Brazil, the Cebus apella monkey (Primates: Cebidae) has been associated with the enzootic cycle of Leishmania (V.) shawi, a dermotropic parasite causing American cutaneous leishmaniasis (ACL). It has also been successfully used as animal model for studying cutaneous leishmaniasis. In this work, there has been investigated its susceptibility to experimental Leishmania (L.) infantum chagasi-infection...