2 documents found, page 1 of 1
Diferenças clínicas entre gêmeas idênticas com anemia falciforme
Laurentino, Marilia Rocha; Almeida Filho, Tarcísio Paulo de; Maia Filho, Pedro A.; Nascimento, Francisco O. F.; Advincula, Adlene F.Sickle cell anemia (SCA) is a genetic disease that causes important clinical manifestations due to chronic hemolysis and vascular occlusion. The aim of this study was to report a rare case of monozygotic twins diagnosed with SCA, presenting a different clinical characteristic. An interview with the patients was carried out and the medical records were consulted. One patient has a history of malleolar ulcer in t...
Methemoglobin measure in adult patients with sickle-cell anemia : influence of ...
Laurentino, Marilia Rocha; Carvalho, Teresa Maria de Jesus Ponte; Santos, Talyta Ellen de Jesus dos; Barbosa, Maritza CavalcanteIntroduction: Hemoglobin S (HbS) is unstable hemoglobin that easily oxidizes, causing methemoglobin (MetHb) increased production in patients with sickle-cell anemia (SCA). Objectives: To determine MetHb levels and the influence of hydroxyurea (HU) therapy on this marker in patients with SCA. Materials and methods: Blood samples from 53 patients with SCA at the steady-state, with and without HU therapy, and 30 h...