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Pattern of hemolysis parameters and association with fetal hemoglobin in sickle...
Moreira,Juliane Almeida; Laurentino,Marília Rocha; Machado,Rosângela Pinheiro Gonçalves; Barbosa,Maritza Cavalcante; Gonçalves,Ronaldo PinheiroObjective: This study aimed to evaluate the influence of fetal hemoglobin (Hb F) on hemolysis biomarkers in sickle cell anemia patients. Methods: Fifty adult sickle cell anemia patients were included in the study. All patients were taking hydroxyurea for at least six months and were followed at the outpatient clinic of a hospital in Fortaleza, Ceará, Brazil. The control group consisted of 20 hemoglobin AA indivi...
Influence of ?S-globin haplotypes and hydroxyurea on tumor necrosis factor-alph...
Laurentino,Marília Rocha; Maia Filho,Pedro Aurio; Barbosa,Maritza Cavalcante; Bandeira,Izabel Cristina Justino; Rocha,Lilianne Brito da SilvaBackground: Sickle cell anemia is a chronic inflammatory disease characterized by an increased production of proinflammatory cytokines including tumor necrosis factor-alpha. Hydroxyurea, by decreasing the polymerization of hemoglobin, reduces inflammatory states. The effect of the genetic polymorphisms of sickle cell patients on tumor necrosis factor-alpha levels remains unknown. Objective: The aim of this stud...