2 documents found, page 1 of 1
Design and synthesis of new benzophenone derivatives with in vivo anti-inflamma...
Januário, Jaqueline Pereira; Souza, Thiago Belarmino de; Lavorato, Stefânia Neiva; Maiolini, Tatiane Cristina Silva; Domingos, Olívia da SilvaA series of novel benzophenone derivatives containing a thiazole heterocyclic nucleus were designed by molecular hybridization. Molecular docking studies have demonstrated the inhibitory potential of the designed compounds against cyclooxygenase (COX) isoenzymes. These compounds were synthesized, characterized, and evaluated for their anti-inflammatory properties by the croton oil-induced ear edema assay to exa...
Synthesis, antileishmanial activity and QSAR studies of 2-chloro- N -arylacetam...
Lavorato, Stefânia Neiva; Duarte, Mariana Costa; Andrade, Pedro Henrique Rocha De; Coelho, Eduardo Antonio Ferraz; Alves, Ricardo JoséWe describe herein the synthesis and evaluation of the antileishmanial activity against promastigote forms of Leishmania amazonensis and cytotoxicity to murine macrophages of a series of 2-chloro-N-arylacetamide derivatives. All compounds were active, except one (compound 3). Compound 5 presented the most promising results, showing good antileishmanial activity (CI50=5.39±0.67 µM) and moderate selectivity (SI=6...