54 documents found, page 1 of 6

The trends of Portugal’s 100 most popular sunscreens : a cosmetic consumer prof...

Poster presented at the 7th CiiEM International Congress: Empowering One Health to Reduce Social Vulnerabilities. Monte de Caparica, 2-4 july 2025

Bridging generations through integrative learning, research, and community care...

Communication abstract presented at the EAFP Annual Conference 2025 – “Pharmaceutical Education & Research: SWOT Analysis”. Faculty of Pharmacy, University of Coimbra, 13th-15th of May 2025

Non multa sed multum - Américo da Costa Ramalho 1921-2021

In vitro studies into establishing therapeutic bioequivalence of complex topica...

Over the past decade, topically applied drug products have experienced extraordinary price increases, due to the shortage of multisource generic drug products. This occurrence is mainly related to the underlying challenges evolved in topical bioequivalence documentation. Although there has been continuing regulatory efforts to present surrogate in vitro methods to clinical endpoint studies, there is still a con...

Rheology of Complex Topical Formulations: An Analytical Quality by Design Appro...

Analytical method validation ensures that a method provides trustworthy information about a particular sample when applied in accordance with the predefined protocol. According to regulatory standards, the rheological characteristics of topically applied semisolid formulations are one of the key elements involved in microstructure equivalence documentation. Therefore, for generic drug product manufacturers, it ...

Amorphous nasal powder advanced performance : in vitro/ex vivo studies and corr...

Purpose: Amorphous solid dispersions (ASD) for nasal delivery offer the opportunity to increase drug release performance, while using polymers with mucoadhesive properties. The aim of the present study was to apply this solubility enhancement technique to a poorly soluble drug for nasal delivery, while comparing two particle engineering strategies, namely spray dried microparticles and chimeral agglomerates, wi...

Development of a new hydrogel for the prevention of allergic contact dermatitis

Allergic contact dermatitis (ACD) is the most prevalent occupational disease and the most common form of immunotoxicity in humans. Preventing exposure to the triggering allergens is the mainstay of treatment. However, avoidance is not always possible in an occupational setting. From a pathophysiological point of view, a variety of events are involved in the development of ACD, including the formation of immunog...

Eficácia profilática da brimonidina no pico tensional após injeção intra-vítrea...

Objetivos: Determinar a eficácia da brimonidina tópica na prevenção do pico de pressão intra-ocular (PIO) que ocorre após a injeção de fármacos intra-vítreos. Material e Métodos: Ensaio clínico randomizado, do tipo crossover, com inclusão de doentes submetidos a duas injeções intra-vítreas (IIV), em meses consecutivos, de bevacizumab. Aleatorização de cada doente para o grupo de controlo (sem profilaxia) ou par...

Dom Jerónimo Osório e a implantação da Companhia de Jesus em Portugal

A História da Companhia de Jesus na Assistência a Portugal, de Francisco Rodrigues S. J., refere abundantemente a figura de Dom Jerónimo Osório, mas não lhe atribui qualquer papel na vinda dos primeiros jesuítas para Portugal. À luz dos resultados mais recentes da investigação sobre Dom Jerónimo Osório, é possível rever aquela posição e estabelecer dados mais objectivos quer sobre a formação do humanista (que c...

Fast Screening Methods for the Analysis of Topical Drug Products

Considering the recent regulatory requirements, the overall importance of in vitro release testing (IVRT) methods regarding topical product development is undeniable, especially when addressing particulate systems. For each IVRT study, several hundreds of samples are generated. Therefore, developing rapid reversed-phase high-performance liquid chromatography (RP-HPLC) methods, able to provide a real-time drug a...