7 documents found, page 1 of 1
Towards a consensus definition of allostatic load: a multi-cohort, multi-system...
McCrory, C; McLoughlin, S; Layte, R; NiCheallaigh, C; O'Halloran, AM; Barros, H; Berkman, LF; Bochud, M; Crimmins, EM; Farrell, MT; Fraga, S; Grundy, EBackground: Allostatic load (AL) is a multi-system composite index for quantifying physiological dysregulation caused by life course stressors. For over 30 years, an extensive body of research has drawn on the AL framework but has been hampered by the lack of a consistent definition.Methods: This study analyses data for 67,126 individuals aged 40-111 years participating in 13 different cohort studies and 40 bio...
Special Report: The Biology of Inequalities in Health: The Lifepath Consortium
Vineis, P; Avendano-Pabon, M; Barros, H; Bartley, M; Carmeli, C; Carra, L; Chadeau-Hyam, M; Costa, G; Delpierre, C; D'Errico, A; Fraga, S; Giles, GFunded by the European Commission Horizon 2020 programme, the Lifepath research consortium aimed to investigate the effects of socioeconomic inequalities on the biology of healthy aging. The main research questions included the impact of inequalities on health, the role of behavioral and other risk factors, the underlying biological mechanisms, the efficacy of selected policies, and the general implications of ...
Maternal educational inequalities in measured body mass index trajectories in t...
McCrory, C; Leahy, S; Ribeiro, AI; Fraga, S; Barros, H; Avendano, M; Vineis, P; Layte, R; LIFEPATH consortiumBackground Social inequalities in the prevalence of childhood overweight and obesity are well-established, but less is known about when the social gradient first emerges and how it evolves across childhood and adolescence. Objective This study examines maternal education differentials in children's body mass trajectories in infancy, childhood and adolescence using data from four contemporary European child coho...
A Comparative Analysis of the Status Anxiety Hypothesis of Socio-economic Inequ...
Layte, R; McCrory, C; Cheallaigh, CN; Bourke, N; Kivimaki, M; Ribeiro, AI; Stringhini, S; Vineis, PThe status anxiety hypothesis proposes that systematic inflammation as a consequence of chronic psycho-social stress is a possible pathway linking socio-economic position (SEP) to premature ageing and is a possible explanation for cross-national variation in patterns of health and well-being. Harmonised data from the LIFEPATH consortium on 18,349 individuals aged 50 to 75 and 30,632 observations are used to mea...
Socioeconomic status, non-communicable disease risk factors, and walking speed ...
Stringhini, S; Carmeli, C; Jokela, M; Avendaño, M; McCrory, C; d'Errico, A; Bochud, M; Barros, H; Costa, G; Chadeau-Hyam, M; Delpierre, C; Gandini, MObjective To assess the association of low socioeconomic status and risk factors for non-communicable diseases (diabetes, high alcohol intake, high blood pressure, obesity, physical inactivity, smoking) with loss of physical functioning at older ages. Design Multi-cohort population based study. Setting 37 cohort studies from 24 countries in Europe, the United States, Latin America, Africa, and Asia, 1990-2017 P...
Socioeconomic differences in children’s growth trajectories from infancy to ear...
McCrory, C; O'Leary, N; Fraga, S; Ribeiro, AI; Barros, H; Kartiosuo, N; Raitakari, O; Kivimäki, M; Vineis, P; Layte, RBackground Height is regarded as a marker of early-life illness, adversity, nutrition and psychosocial stress, but the extent to which differences in height are determined by early-life socioeconomic circumstances, particularly in contemporary populations, is unclear. This study examined socioeconomic differences in children’s height trajectories from birth through to 21 years of age in four European countries....
Socioeconomic status and the 25 × 25 risk factors as determinants of premature ...
Stringhini, S; Carmeli, C; Jokela, M; Avendaño, M; Muennig, P; Guida, F; Ricceri, F; d'Errico, A; Barros, H; Bochud, M; Chadeau-Hyam, MBackground: In 2011, WHO member states signed up to the 25 × 25 initiative, a plan to cut mortality due to non-communicable diseases by 25% by 2025. However, socioeconomic factors influencing non-communicable diseases have not been included in the plan. In this study, we aimed to compare the contribution of socioeconomic status to mortality and years-of-life-lost with that of the 25 × 25 conventional risk facto...