15 documents found, page 1 of 2
Association between fibroblast growth factor 23 and functional capacity among i...
Araújo,Lara Miguel Quirino; Moreira,Patrícia Ferreira do Prado; Almada Filho,Clineu de Mello; Araújo,Luciano Vieira de; Costa,Aline GranjaABSTRACT Objective To examine the association of between serum fibroblast growth factor 23 and the functional capacity among independent individuals, aged 80 or older. Methods The functional capacity of 144 elderly was assessed by Instrumental Activities of Daily Living, cognitive tests, handgrip strength and the timed ability to rise from a chair and sit down five times. Fibroblast growth factor 23 was measure...
A two-year follow-up of asfotase alfa replacement in a patient with hypophospha...
Reis,Fernanda Salles; Gomes,Débora Cristiane; Arantes,Henrique Pierotti; Lazaretti-Castro,MariseSUMMARY Hypophosphatasia (HPP) is a rare disease with a high mortality rate in its severe forms. It is caused by mutations within the gene encoding the tissue-nonspecific alkaline phosphatase (TNSALP), an enzyme responsible for bone mineralization. In 2015, the Food and Drug Administration approved the use of asfotase alfa, the first medication showing benefit in the treatment of HPP. We describe a case with a ...
Reference values of 25-hydroxyvitamin D revisited: a position statement from th...
Moreira,Carolina Aguiar; Ferreira,Carlos Eduardo dos S; Madeira,Miguel; Silva,Barbara Campolina Carvalho; Maeda,Sergio Setsuo; Batista,Marcelo CidadeABSTRACT Hypovitaminosis D is a common condition with a negative impact on health. This statement, prepared by experts from the Brazilian Society of Endocrinology and Metabolism and the Brazilian Society of Clinical Pathology/Laboratory Medicine, includes methodological aspects and limitations of the measurement of 25-hydroxyvitamin D [25(OH)D] for identification of vitamin D status, and identifies individuals ...
Reasons to avoid vitamin D deficiency during COVID-19 pandemic
Santos,Rodrigo Nolasco dos; Maeda,Sergio Setsuo; Jardim,José Roberto; Lazaretti-Castro,MariseABSTRACT The effects of vitamin D on the musculoskeletal system are well established. Its deficiency causes osteomalacia, secondary hyperparathyroidism, and an increased risk for fractures and falls. However, clinical and experimental evidence points to extra-skeletal actions of vitamin D, including on immune and respiratory systems. Thus, during this COVID-19 pandemic, a possible deleterious role of vitamin D ...
Prevention and treatment of oral adverse effects of antiresorptive medications ...
Madeira,Miguel; Rocha,André Caroli; Moreira,Carolina Aguiar; Aguiar,Águida Maria Menezes; Maeda,Sergio Setsuo; Cardoso,Abel SilveiraABSTRACT Antiresorptive therapy is the main form of prevention of osteoporotic or fragility fractures. Medication-related osteonecrosis of the jaw (MRONJ) is a relatively rare but severe adverse reaction to antiresorptive and antiangiogenic drugs. Physicians and dentists caring for patients taking these drugs and requiring invasive procedures face a difficult decision because of the potential risk of MRONJ. The...
Diagnosis and treatment of hypoparathyroidism: a position statement from the Br...
Maeda,Sergio Setsuo; Moreira,Carolina Aguiar; Borba,Victória Zeghbi Cochenski; Bandeira,Francisco; Farias,Maria Lucia Fleiuss deABSTRACT Objective To present an update on the diagnosis and treatment of hypoparathyroidism based on the most recent scientific evidence. Materials and methods The Department of Bone and Mineral Metabolism of the Sociedade Brasileira de Endocrinologia e Metabologia (SBEM; Brazilian Society of Endocrinology and Metabolism) was invited to prepare a document following the rules set by the Guidelines Program of th...
Lean mass as a determinant of bone mineral density of proximal femur in postmen...
Marin-Mio,Rosangela Villa; Moreira,Linda Denise Fernandes; Camargo,Marília; Périgo,Neide Alessandra Sansão; Cerondoglo,Maysa SeabraABSTRACT Objective: To verify which component of body composition (BC) has greater influence on postmenopausal women bone mineral density (BMD). Subjects and methods: Four hundred and thirty women undergoing treatment for osteoporosis and 513 untreated women, except for calcium and vitamin D. Multiple linear regression analysis was performed in order to correlated BMD at lumbar spine (LS), total femur (FT), fem...
Effects of vitamin D supplementation on pulmonary function in postmenopausal wo...
Nolasco,Rodrigo; Moreira,Linda D. F.; Bocalini,Danilo S.; Fronza,Fernanda C. A. O.; Marin,Rosangela Villa; Lazaretti-Castro,MariseABSTRACT Objective This study sought to investigate the effects of vitamin D supplementation and aquatic exercise on pulmonary function in postmenopausal women. Materials and methods This prospective and controlled study included 104 women (62 ± 6.5 years) divided into three groups: a control group lacking vitamin D and calcium supplementation which remained sedentary (CG; n = 17); a control group receiving vit...
Consensus - reference ranges of vitamin D [25(OH)D] from the Brazilian medical ...
Ferreira,Carlos Eduardo S.; Maeda,Sergio S.; Batista,Marcelo C.; Lazaretti-Castro,Marise; Vasconcellos,Leonardo S.; Madeira,Miguel; Soares,Lilian M.ABSTRACT Introduction: Vitamin D is considered a pre-hormone and plays a crucial role in calcium homeostasis and, consequently, in bone health. The best source of vitamin D is the skin in response to sunlight. Only small amounts of this vitamin are found in some foods (especially fatty fish), which makes availability of vitamin D in the diet limited. Brazilian population studies show that the prevalence of hypo...
Brazilian guidelines for the diagnosis and treatment of postmenopausal osteopor...
Radominski,Sebastião Cézar; Bernardo,Wanderley; Paula,Ana Patrícia de; Albergaria,Ben-Hur; Moreira,Caio; Fernandes,Cesar Eduardo; Castro,Charlles H.M.Abstract Osteoporosis is the leading cause of fractures in the population older than 50 years. This silent disease affects primarily postmenopausal women and the elderly, and the morbidity and mortality rates are high. The main goal of treating osteoporosis is the prevention of fractures. The identification of populations at risk through early diagnosis and treatment is essential. The last Brazilian guideline f...